肠道噬菌体与细菌和宿主互作及其对动物机体健康影响的研究进展

Advances in the Interaction among Gut Phage,Bacteria and Host and Its Impacts on the Animal Host Health

近年来肠道病毒组功能研究日益受到关注,其中肠道噬菌体作为肠道病毒组的主要组成,更是成为了研究热点。大量研究表明,肠道噬菌体种类和数量不仅直接影响肠道微生物菌群区系,还与动物机体存在着密切联系,因此对动物机体健康发挥着重要作用。本文就肠道噬菌体研究进展进行总结,从肠道噬菌体、噬菌体与细菌互作、噬菌体与动物宿主互作以及肠道噬菌体与肠道炎症性疾病、代谢性疾病等疾病的联系等方面进行综述,为深入研究肠道噬菌体对机体健康的影响及其机制提供理论参考和新的思路。

In recent years,the research on the function of gut virome has attracted increasing attention.As a main component of the gut virome,intestinal phage has become a research hotspot.Numerous studies have shown that the diversity and abundance of gut phage not only directly affect the gut microbiota,but also have close correlation with host function,playing an important role in modulation of host health.In this review,we summarize current research progress in the interaction between gut phage and bacteria,the interaction between phage and animal host,and the relationship between gut phage and diseases such as inflammatory bowel disease and metabolic disease.This review will provide a theoretical basis and new perspective for further study on the effect of gut phage on animal health.