生长因子受体结合蛋白7和人表皮生长因子受体2在子宫内膜癌中的表达及其意义

Expressions of growth factor receptor binding protein 7 and human epidermal growth factor receptor 2 in endometrial carcinoma and their significances

目的探讨生长因子受体结合蛋白7(GRB7)和人表皮生长因子受体2(HER2)在子宫内膜癌中的表达及其临床意义。方法采用免疫组织化学法检测2015年5月至2017年9月上海交通大学第六人民医院52例子宫内膜癌组织、38例子宫内膜不典型增生组织和30例正常子宫内膜组织中GRB7和HER2的表达,并分析两者的表达水平与子宫内膜癌患者临床病理特征的关系。结果GRB7在子宫内膜癌、子宫内膜不典型增生及正常子宫内膜组织中的阳性表达率分别为71.2%(37/52)、39.5%(15/38)和13.3%(2/30),组间比较差异有统计学意义(χ^2=35.14,P<0.05);HER2在子宫内膜癌、子宫内膜不典型增生及正常子宫内膜组织中的阳性表达率分别为67.3%(35/52)、34.2%(13/38)和10.0%(3/30),组间比较差异有统计学意义(χ^2=29.36,P<0.05)。不同临床分期、组织学分级和病理类型子宫内膜癌患者的GRB7阳性表达率比较,差异均有统计学意义(均P<0.05);不同临床分期、组织学分级、淋巴结转移和肌层浸润深度子宫内膜癌患者的HER2阳性表达率比较,差异均有统计学意义(均P<0.05)。在子宫内膜癌中GRB7的表达与HER2表达呈正相关(r=0.375,P<0.05)。结论GRB7和HER2在子宫内膜癌组织中均高表达,且其表达与子宫内膜癌的恶性程度密切相关。

ObjectiveTo investigate the expressions of growth factor receptor binding protein 7(GRB7)and human epidermal growth factor receptor 2(HER2)in endometrial carcinoma and their clinical significances.MethodsImmunohistochemistry was used to detect the expressions of GRB7 and HER2 in 52 endometrial carcinoma tissues,38 endometrial atypical hyperplasia tissues and 30 normal endometrial tissues collected from patients in the Sixth People's Hospital of Shanghai Jiao Tong University from May 2015 to September 2017.The relationship between the expressions of GRB7 and HER2 and clinicopathological features of endometrial carcinoma patients was analyzed.ResultsThe positive expression rates of GRB7 in endometrial carcinoma,endometrial atypical hyperplasia and normal endometrial tissues were 71.2%(37/52),39.5%(15/38),and 13.3%(2/30),respectively,and the difference was statistically significant(χ^2=35.14,P<0.05).The positive expression rates of HER2 in endometrial carcinoma,endometrial atypical hyperplasia and normal endometrial tissues were 67.3%(35/52),34.2%(13/38),and 10.0%(3/30),respectively,and the difference was statistically significant(χ^2=29.360,P<0.05).The positive expression rates of GRB7 in endometrial carcinoma patients with different clinical stages,histological grades and pathological types were statistically significant(all P<0.05).The positive expression rates of HER2 in endometrial carcinoma patients with different clinical stages,histological grades,lymph nodes metastasis and myometrial invasion were statistically significant(all P<0.05).The expression of GRB7 in endometrial carcinoma was positively correlated with the expression of HER2(r=0.375,P<0.05).ConclusionThe high expressions of GRB7 and HER2 in endometrial carcinoma are closely related to the malignant degree of endometrial carcinoma.