老年人急性早幼粒细胞白血病治疗进展

Treatment progress of elderly patients with acute promyelocytic leukemia

急性早幼粒细胞白血病(APL)是一种以异常早幼粒细胞增多、骨髓造血功能衰竭并伴t(15;17)染色体易位为特征的特殊类型急性髓系白血病。随着治疗的进展,APL已成为分子靶向治疗的典范,但老年APL患者的总体生存情况仍不容乐观。全反式维甲酸、砷剂及新药的研发,为老年APL患者提供了新的治疗选择。文章对老年人APL治疗进展进行综述。

Acute promyelocytic leukemia(APL)is a special subtype of acute myeloid leukemia characterized by an increase of abnormal promyelocytic cells,failure of bone marrow hematopoietic function accompanied by the chromosome translocation t(15;17).APL has become one of the best paradigms of successful molecule targeted therapy with the development of treatments;however,the overall survival(OS)of elderly APL patients was not optimistic.The discovery of all-trans retinoic acid,arsenic and new drugs has provided new therapeutic choices for elderly patients with APL.This article reviews the treatment progress of elderly patients with APL.