摘要
在氧化应激性疾病发生发展过程中,活性氧(reactive oxygen species,ROS)的清除障碍或生成过多导致爆发性释放后,可损伤机体各组织器官。最新研究证明:核因子E2相关因子2/血红素加氧酶-1(nuclear factor erythroid-2-related actor 2/heme oxygenase 1,Nrf2/HO-1)信号轴通过发挥抗炎、抗氧化、减少线粒体损伤、调节钙离子内流、调控细胞凋亡(apoptosis)、焦亡(pyroptosis)、铁死亡(ferroptosis)及自噬(autophagy)等作用,抵抗氧化应激损伤,这为它在不同脏器(呼吸、心血管、神经、消化、泌尿、血液)的氧化应激性疾病中的治疗潜力提供了分子机制上的理论基础。因此,有效调控Nrf2/HO-1信号轴可成为治疗氧化应激性疾病的重要靶点。
In the development of oxidative stress-relevant diseases,reactive oxygen species(ROS)removal obstacle or excess production results in the damage of the body tissues and organs.Recent studies have demonstrated that nuclear factor E2-related factor 2/heme oxygenase-1(Nrf2/HO-1)axis played a significant role in anti-oxidative stress.The Nrf2/HO-1 axis counteracts oxidative stress injury by its resistance to inflammation,oxidation,mitochondrial damage and calcium influx,apoptosis,pyroptosis,ferroptosis and autophagy,which provides a theoretical basis for its therapeutic effect on various oxidative stress-relevant diseases in multiple organs(respiratory,cardiovascular,nervous,digestive,urinary and blood systems).Therefore,effective regulation of the Nrf2/HO-1 signal axis can be an important strategy for treatment of oxidative stress-relevant diseases.
作者
王甜甜
陈淳媛
杨雷
曾志辉
曾茂君
蒋文
刘琳
赵明一
WANG Tiantian;CHEN Chunyuan;YANG Lei;ZENG Zhihui;ZENG Maojun;JIANG Wen;LIU Lin;ZHAO Mingyi(Guangdong Academy of Medical Sciences,Guangzhou 510080;Department of Clinical Medicine,Xiangya School of Medicine,Central South University,Changsha 410013;Guangdong Cardiovascular Institute,Department of Cardiovascular Surgery,Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080;Department of Pediatrics,Maternal and Child Health Hospital of Changde City,Changde Hunan 415000,China)
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2019年第1期74-80,共7页
Journal of Central South University ：Medical Science
基金
国家自然科学基金(81500231)
湖南省自然科学基金(2018JJ3786)
中南大学湘雅三医院"新湘雅人才工程"(JY201524)~~
