输血治疗对早产贫血患儿脑及肠道组织氧饱和度的影响

Effect of blood transfusion therapy on oxygen saturation in brain and intestinal tissues of children with premature birth and anaemia

目的:研究输血治疗对早产贫血患儿脑及肠道组织氧饱和度的影响。方法:选择本院95例早产贫血患儿作为研究对象,根据贫血程度分为轻度组30例、中度组30例、重度组35例,另选择35例无贫血早产儿作为对照组。比较4组的基础生命体征、Hb与Hct、脑及肠道组织氧饱和度。结果:4组治疗后的SBP、DBP比较,差异均无统计学意义(P>0.05);对照组、轻度组治疗后的HR、RR显著高于重度组治疗后的HR、RR,中度组治疗后的RR显著低于对照组治疗后的RR,差异均有统计学意义(P<0.05)。对照组、轻度组治疗后的Hb显著高于中度组、重度组治疗后的Hb,中度组治疗后的Hb显著高于重度组治疗后的Hb,差异均有统计学意义(P<0.05);对照组、轻度组治疗后的Hct显著高于重度组治疗后的Hct,差异均有统计学意义(P<0.05);中度组治疗后的Hct与轻度组、重度组治疗后的Hct比较,差异均无统计学意义(P>0.05)。对照组、轻度组治疗后的脑氧饱和度显著高于重度组治疗后的脑氧饱和度,对照组治疗后的肠道组织氧饱和度显著高于重度组治疗后的肠道组织氧饱和度,差异均有统计学意义(P<0.05);重度组与中度组治疗后的脑氧饱和度比较,重度组、中度组、轻度组治疗后的肠道组织氧饱和度比较,差异均无统计学意义(P>0.05)。结论:输血治疗能在不影响血压的情况下,显著提高早产贫血患儿脑及肠道组织氧饱和度,改善患儿贫血程度,可在严格把握临床指征提前下合理运用。

Objective:To study the effect of blood transfusion therapy on oxygen saturation in brain and intestinal tissues of children with premature birth and anaemia.Methods:Ninety-five children with premature birth and anaemia in our hospital from August 2016 to July 2018 were selected as subjects.According to the degree of anemia,they were divided into three groups,with 30 patients in the mild group,30 in the moderate group and 35 in the severe group.35 premature without anemia were set as the control group.Basal vital signs,Hb and Hct,brain and intestinal tissue oxygen saturation were compared among the four groups.Results:There were no significant differences in SBP and DBP between the four groups after treatment(P >0.05).The HR and RR after treatment in the control group and the mild group were significantly higher than those in the severe group.The RR was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).The Hb in the control group and the mild group was significantly higher than that in the moderate group and the severe group.The Hb in the moderate group was significantly higher than that in the severe group.The difference was statistically significant(P<0.05%).Hct in the control group and the mild group was significantly higher than that in the severe group(P<0.05).The Hct in the moderate group was treated with the mild group and the severe group.After Hct comparison,the difference was not statistically significant(P >0.05).The cerebral oxygen saturation after treatment in the control group and the mild group was significantly higher than that in the severe group.The intestinal tissue oxygen saturation after treatment was significantly higher than that in the severe group.The difference was statistically significant(P<0.05).Compared with the cerebral oxygen saturation after treatment in the severe group and the moderate group,the intestinal tissue oxygen saturation after treatment in the severe group,the moderate group and the mild group,there was no significant difference in the difference(P >0.05).Conclusion:Blood transfusion therapy can significantly improve the oxygen saturation of brain and intestinal tissues in children with premature anaemia without affecting blood pressure,and improve the degree of anemia in children.It can be used reasonably in strict control of clinical indications.