骨肉瘤中Micro-RNA的研究进展

Research Progress of MicroRNA in Osteosarcoma

骨肉瘤是最常见的骨恶性肿瘤,是一种起源于间叶组织的恶性肿瘤,好发于青少年,由于其发病机制十分复杂,目前没有特别有效的治疗手段,经典的治疗方法是手术辅以新辅助化疗,但患者五年生存率最高仍只能达到70%左右。微小RNA是一种小型的非编码RNA,被广泛证明在恶性肿瘤的发生发展、侵袭、转移等方面起到调控作用,它与骨肉瘤又有着何种联系,本文就是对骨肉瘤中micro-RNA的研究进展做一综述。

Osteosarcoma is the most common malignant bone tumor.It is a malignant tumor originating in the mesenchymal tissue,occuring in adolescents.Because of its complicated pathogenesis,there is no effective treatment so far.The classical treatment method is surgery and Neoadjuvant chemotherapy,but the patient's five-year survival rate is still only up to about 70%.MicroRNA is a kind of small noncoding RNA,which has been proved to play an important role in the regulation of the occurrence,development,invasion and metastasis of malignant tumors.This article is a review of the research progress of micro-RNA in osteosarcoma.