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头孢类抗生素的热分解动力学研究

Study on Thermal Decomposition Kinetics of Cephalosporin Antibiotics
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摘要 采用热重分析法详细研究了头孢克肟和头孢喹肟两种头孢类抗生素的热稳定性及热分解过程,利用Kissinger法和Ozawa-Flynn-Wall法计算出两种抗生素的热分解动力学参数,Ea和lnA等。利用红外光谱分析了两种抗生素分解前后发生的结构变化。结果表明,Kissinger法和Ozawa-Flynn-Wall法计算得到的头孢克肟的E_a分别为39. 18 kJ/mol和41. 91 kJ/mol,ln A为8. 46 s^(-1);头孢喹肟的E_a分别为27. 32 kJ/mol和28. 91 kJ/mol,lnA为19. 4 s^(-1)。头孢克肟的分解活化能E_a高于头孢喹肟,说明其热稳定性优于后者。 The thermal stability and decomposition process of cefixime and cefquinoxime were studied in detail by thermogravimetric analysis.Kissinger method and Ozawa-Flynn-Wall method were used to calculate the thermal decomposition kinetic parameters of these two cephalosporins,including Ea and lnA.The possible structural changes of the two antibiotics before and after decomposition were analyzed by infrared spectroscopy.The results showed that Ea of the cefixime calculated by Kissinger method and Ozawa-Flynn-Wall method were 39.18 kJ/mol and 41.91 kJ/mol,respectively,and lnA was 8.46 s^-1.E a of the cefixime was 27.32 kJ/mol and 28.91 kJ/mol,respectively,and lnA was 19.4 s^-1.The decomposition activation energy of cefixime was higher than cefquinoxime,indicating that its thermal stability was better than that of cefquinoxime.
作者 肖红艳 张丽影 杨一璠 吴亚多 李容庆 XIAO Hong-yan;ZHANG Li-ying;YANG Yi-fan;WU Ya-duo;LI Rong-qing(Department of Chemical Engineering,Dalian Minzu University,Liaoning Dalian 116600,China)
出处 《广州化工》 CAS 2019年第1期43-45,共3页 GuangZhou Chemical Industry
基金 辽宁省自然科学基金项目(No:20180550977) 大连民族大学大学生创新创业训练计划项目(No:201712026222)
关键词 头孢克肟 头孢喹肟 热分解动力学 活化能 指前因子 cefixime cefquinoxime thermal decomposition kinetics activation energy preexponential factor
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