小鼠实验性肝损伤模型的研究进展

A review of experimental liver injury models in mice

针对实验目的不同选择合适的小鼠肝损伤动物模型对于临床上肝病的防治、发病机制的研究和护肝药物的筛选都有着重要意义。依据国内外参考文献将肝损伤小鼠模型归纳为化学性、药物性、免疫性、酒精性、肝部分切除术等几类。以小鼠肝损伤动物模型分类为切入点,对其发病机制、药物剂量、成模时间、适用范围及优缺点进行综述,以期为小鼠实验性肝损伤模型的选择提供一个参考。

To select the appropriate mouse model of liver injury is of great significance for the research on prevention and treatment of liver disease,the study of its pathogenesis and the screening of drugs to protect the liver.According to references published internationally,mouse models of liver injury were classified into chemical,pharmacological,immunological,alcoholic,and partial hepatectomy studies.Based on the classification of models of liver injury in mice,the pathogenesis,dosage of drugs,time of model formation,applicable scope,and advantages and disadvantages were reviewed to provide a reference for the selection of experimental mouse liver injury models.