布地奈德联合盐酸氨溴索雾化吸入在慢性阻塞性肺疾病急性加重期中的疗效观察

Therapeutic effect of budesonide combined with ambroxol hydrochloride nebulization on acute exacerbation of chronic obstructive pulmonary disease

目的探讨布地奈德联合盐酸氨溴索雾化吸入在慢性阻塞性肺疾病急性加重期中的疗效。方法将82例慢性阻塞性肺疾病急性加重期患者随机分为对照组和研究组,每组41例。对照组采用抗感染、吸氧、解痉等常规治疗,研究组在常规治疗基础上使用布地奈德联合盐酸氨溴索雾化吸入。治疗7 d后,比较两组患者临床有效率、肺功能以及用药安全性。结果治疗后,两组患者FEV1和FEV1/FVC较治疗前均明显升高(P<0.05),但与对照组相比,研究组FEV1和FEV1/FVC升高更加明显,差异具有统计学意义(P<0.05)。对照组和研究组的总有效率分别为70.7%和92.7%,差异具有统计学意义(P<0.05)。对照组和研究组的血、尿常规以及肝、肾功能未见明显异常。结论布地奈德联合盐酸氨溴索雾化吸入在慢性阻塞性肺疾病急性加重期中的疗效确切,能改善患者肺功能,提高临床治疗总有效率。

Objective To investigate the efficacy of budesonide combined with ambroxol hydrochloride nebulization in treatment of acute exacerbation of chronic obstructive pulmonary disease.Methods Eighty-two patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into control group and study group,with 41 cases in each group.The control group was treated with anti-infective,oxygen-absorbing,antispasmodic and other conventional treatments.The study group was treated with budesonide and ambroxol hydrochloride nebulization on the basis of conventional treatment.After 7 days of treatment,the clinical efficacy,lung function,and medication safety of the two groups were compared.Results After treatment,the FEV1 and FEV1/FVC of the two groups were significantly higher than those before treatment(P<0.05),but the increase of FEV1 and FEV1/FVC in the study group was more significant higher than those in the control group,and the difference was statistically significant(P<0.05).The total effective rates of the control group and the study group were 70.7%and 92.7%,respectively,and the difference was statistically significant(P<0.05).There were no significant abnormalities in blood and urine routine tests and liver and kidney function in the control group and the study group.Conclusion Budesonide combined with ambroxol hydrochloride nebulization in treatment of acute exacerbation of chronic obstructive pulmonary disease can improve the lung function of patients and improve the total effective rate of clinical treatment.