二甲双胍联合西格列汀治疗2型糖尿病的效果观察

Effect of metformin combined with sitagliptin in treatment of type 2 diabetes

目的探讨二甲双胍联合西格列汀治疗2型糖尿病的临床效果。方法选取2016年4月～2018年4月本院收治的114例2型糖尿病患者进行研究分析,按照随机分配的原则将其分成两组。对照组57例患者予以西格列汀治疗,研究组57例患者予以二甲双胍、西格列汀治疗,比较两种治疗方法治疗2型糖尿病的临床效果。结果治疗后,研究组的BMI、FPG、2 h PG、HbA1c指标水平均显著低于对照组(P<0.05);研究组的不良反应情况(12.28%)明显少于对照组(24.56%)(P<0.05)。结论对2型糖尿病患者采用二甲双胍联合西格列汀治疗,既可显著改善糖尿病患者的临床症状,不良反应少,又可增强治疗安全性,与单用西格列汀相比,临床疗效更为显著。

Objective To investigate the clinical effect of metformin combined with sitagliptin in treatment of type 2 diabetes.Methods A total of 114 patients with type 2 diabetes admitted in our hospital from April 2016 to April 2018 were enrolled in the study and divided into two groups according to the principle of random assignment.57 patients in the control group were treated with sitagliptin,and 57 patients in the study group were treated with metformin and sitagliptin.The clinical effects between the two treatments for type 2 diabetes were compared.Results After treatment,the BMI,FPG,2hPG,and HbA1c levels in the study group were significantly lower than those in the control group(P<0.05).The incidence of adverse reaction in the study group(12.28%)was significantly less than that in the control group(24.56%)(P<0.05).Conclusion The use of metformin combined with sitagliptin in patients with type 2 diabetes can significantly improve the clinical symptoms of diabetic patients,with fewer adverse reactions,and can enhance treatment safety,and has more significant clinical efficacy than sitagliptin alone.