尼可地尔对稳定型微血管病性心绞痛治疗效果

Treatment effect of nicorandil on stable microangiopathic angina pectoris

目的探析尼可地尔对稳定型微血管病性心绞痛的治疗效果。方法 84例稳定型微血管病性心绞痛患者,随机分为对照组和观察组,每组42例。对照组患者采用曲美他嗪治疗,观察组患者在对照组基础上加用尼可地尔治疗。比较两组患者的治疗效果、心绞痛发作次数和不良反应发生情况。结果观察组患者显效22例,有效18例,无效2例,总有效率为95.2%;对照组患者显效18例,有效16例,无效8例,总有效率为81.0%;观察组患者治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者心绞痛发作次数比较差异无统计学意义(P>0.05);治疗后,观察组患者心绞痛发作次数为(4.8±1.2)次/周,少于对照组的(7.4±1.6)次/周,差异具有统计学意义(P<0.05)。治疗过程中两组均未出现严重不良反应,两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论尼可地尔的应用可有效提高稳定型微血管性心绞痛的治疗效果,减少心绞痛发作次数,应用价值较高。

Objective To discuss and analyze the effect of nicorandil in the treatment of stable microangiopathic angina pectoris.Methods A total of 84 patients with stable microangiopathic angina pectoris were randomly divided into control group and observation group,with 42 cases in each group.The control group was treated with trimetazidine,and the observation group was treated with nicorandil on the basis of the control group.Comparison were made on treatment effect,frequency of angina attacks and the occurrence of adverse reactions between the two groups.Results The observation group had 22 excellent cases,18 effective cases,and 2 ineffective cases,with total effective rate as 95.2%,while the control group had 18 excellent cases,16 effective cases and 8 ineffective cases,with total effective rate as 81.0%.The observation group had higher total effective rate than the control group,and the difference was statistically significant(P<0.05).Before treatment,both groups had no statistically significant difference in frequency of angina attacks(P >0.05).After treatment,the observation group had less frequency of angina attacks as(4.8±1.2)times/week than(7.4±1.6)times/week in the control group,and the difference was statistically significant(P<0.05).No serious adverse reactions were found in the two groups during the treatment.There was no significant difference in the incidence of adverse reactions between the two groups(P >0.05).Conclusion Application of nicorandil can effectively improve the effect of stable microangiopathic angina pectoris and reduce the frequency of angina attacks.This method contains high application value.