初诊老年2型糖尿病患者使用门冬胰岛素30联合二甲双胍治疗的临床疗效

Clinical efficacy of insulin aspart 30 combined with metformin in newly diagnosed elderly patients with type 2 diabetic mellitus

目的研究初诊老年2型糖尿病(T2DM)患者使用门冬胰岛素30联合二甲双胍治疗的临床疗效。方法 90例初诊老年2型糖尿病患者,根据电脑随机分配原则分为对照组和观察组,各45例。对照组患者实施门冬胰岛素30进行治疗,观察组患者实施门冬胰岛素30联合二甲双胍治疗,比较两组患者血糖水平以及不良反应发生情况。结果观察组患者空腹血糖为(6.03±1.52)mmol/L,餐后2 h血糖为(8.42±1.64)mmol/L,糖化血红蛋白为(6.23±1.74)%;对照组患者空腹血糖为(6.69±1.45)mmol/L,餐后2 h血糖为(9.68±1.57)mmol/L,糖化血红蛋白为(7.32±1.58)%;观察组患者空腹血糖、餐后2 h血糖、糖化血红蛋白水平均明显低于对照组,差异具有统计学意义(P<0.05)。观察组患者不良反应发生率为2.22%,明显低于对照组的22.22%,差异具有统计学意义(P<0.05)。结论初诊老年2型糖尿病患者使用门冬胰岛素30联合二甲双胍治疗临床效果显著,且安全性较高,值得应用。

Objective To study the clinical efficacy of insulin aspart 30 combined with metformin in newly diagnosed elderly patients with type 2 diabetic mellitus(T2DM).Methods A total of 90 newly diagnosed elderly patients with type 2 diabetic mellitus were divided by computer random allocation principle into control group and observation group,with 45 cases in each group.The control group was treated with insulin aspart 30,and the observation group was treated with insulin aspart 30 and metformin.The blood glucose level and occurrence of adverse reactions between the two groups was compared.Results The observation group had fasting blood glucose as(6.03±1.52)mmol/L,2 h postprandial blood glucose as(8.42±1.64)mmol/L and glycosylated hemoglobin as(6.23±1.74)%,which were(6.69±1.45)mmol/L,(9.68±1.57)mmol/L and(7.32±1.58)%in the control group.The observation group had obviously lower fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin than the control group,and the difference was statistically significant(P<0.05).The observation group had obviously lower incidence of adverse reactions as 2.22%than 22.22%in the control group,and the difference was statistically significant(P<0.05).Conclusion Combination of insulin aspart 30 and metformin shows remarkable clinical efficacy in treating newly diagnosed elderly patients with type 2 diabetic mellitus with high safety.It is worthy of application.