运动训练对肝硬化患者运动功能的疗效观察

Effects of an exercise program in patients with hepatic cirrhosis

目的:观察运动训练对肝硬化患者运动功能的影响。方法:将20例肝硬化患者随机分为运动组和常规组各10例,均接受常规药物治疗,运动组在此基础上给予8周的适度运动训练。分别在治疗前后采用超声下股四头肌的厚度评估肌肉质量,等速肌力测试评估伸膝肌力,6min步行距离(6MWD)评估运动能力,同时采用慢性肝病调查问卷(CLDQ)评估健康相关生活质量(HRQoL),监测运动前后肝硬化严重程度及血液指标变化。结果:干预后运动组患者的6MWD、股四头肌的厚度、伸膝肌力、CLDQ评估中乏力、活动2项评分较治疗前及常规组比较均有显著提高(P<0.05)。结论:适度的运动训练可提高肝硬化患者的运动功能,提高健康相关生活质量。

Objective:To observe the effect of an exercise program in patients with hepatic cirrhosis.Methods:Twenty patients with hepatic cirrhosis were randomly divided into exercise group and control group,n=10 in each group.The control group and exercise group were treated with routine medical management.The exercise group were additionally given the program of moderate exercise for 8 weeks under supervision of a physiotherapist.Before and after the 8-week intervention,we determined exercise capacity(6-minute walk distance,6 MWD),quadriceps muscle thickness(measured by ultrasound),isometric knee extension(isometric dynamometer),and health-related quality of life(HRQoL)by answers from Chronic Liver Disease Questionnaires(CLDQ).Results:After intervention,6 MWD,quadriceps muscle thickness,isometric knee extension,and scores of fatigue and activity in CLDQ were significantly increased in exercise group as compared with those before intervention and in control group(P<0.05 for all).Conclusion:Physical exercise could improve exercise capacity,muscle mass,and HRQoL in patients with hepatic cirrhosis.