聚焦超声对宫颈持续高危型HPV感染治疗的疗效研究

Effects of focused ultrasound on the treatment of cervical persistent high-risk HPV infection

目的探讨聚焦超声治疗宫颈高危型人乳头瘤病毒(HPV)感染的安全性和有效性,为宫颈持续高危型HPV感染的治疗探寻安全有效的微创治疗模式。方法选择该院465例持续高危型HPV感染的慢性宫颈炎患者,分A组(聚焦超声治疗)、B组(干扰素泡腾阴道上药治疗)、C组(单纯随访对照),比较3组治疗后3、6个月的宫颈评分及高危型HPV转阴率。结果 A、B组治疗后3、6个月宫颈评分较C组有明显改善,且两组HPV感染治疗有效率高于C组,其中A组3、6个月HPV治疗有效率(82.01%、91.01%)明显高B组(62.50%、75.00%),差异有统计学意义(P<0.05)。结论聚焦超声治疗宫颈高危型HPV感染转阴率高,可降低高危型HPV持续感染致宫颈癌的风险。

Objective To explore the safety and efficacy of focused ultrasound on the treatment of cervical persistent high-risk HPV infection,and to explore the safe and effective minimally invasive treatment.Methods 465 cases of chronic cervicitis with persistent high-risk HPV infection were selected and divided into group A(focused ultrasound therapy),group B(interferon effervescent at vagina),group C(only followed-up as controls).Cervical score and the negative conversion ratio of high-risk HPV after 3 and 6 months were compared in these groups.Results Compared with group C,cervical score of group A and B significantly improved after 3 and 6 months.And the effective rate of HPV treatment in the two groups was higher than that in group C.The effective rate of HPV infective treatment at 3-and 6-month in group A(82.01%,91.01%)was significantly higher than that in group B(62.50%,75.00%),the difference was statistically significant(P<0.05).Conclusion Focused ultrasound in the treatment of cervical high-risk HPV infection has a high negative conversion ratio,which reduces the risk of persistent infection.