参茯五味芍药汤对突发性耳聋治疗前后信噪比的影响

The Influence of Shenfu Wuwei Shaoyao Decoction on Signal to Noise Ratio Before and After Treatment of Sudden Deafness

目的探讨畸变产物耳声发射(DPOAE)中信噪比的变化,评价参茯五味芍药汤治疗突发性耳聋的疗效。方法 120例突发性耳聋患者,随机分为治疗组(60例)和对照组(60例),前者采用参茯五味芍药汤结合综合治疗的方法,后者仅采用综合方法治疗,疗程2周,治疗前后观察2组的临床疗效。结果治疗组治疗前的耳声发射通过率为36.7%,治疗后提高到71.7%;对照组治疗前的耳声发射通过率为43.3%,治疗后提高到58.3%。治疗组对耳声发射通过率的提高明显优于对照组(P<0.01)。比较各频率点信噪比(SNR),治疗组能有效提高0.5、1、2、8 k Hz频率点的SNR,且优于对照组(P<<0.05)。结论参茯五味芍药汤治疗突发性耳聋的疗效明显,耳声发射对于评价突发性耳聋的临床疗效具有重要的意义。

Objective To investigate the effect of the change of the noise ratio of distortion product otoacoustic emissions (DPOAE) on sudden deafness. Methods 120 patients with sudden deafness were randomly divided into two groups, 60 cases were treated with Shenfu Wuwei Shaoyao decoction as treating group and 60 were cases treated with chemical drugs as control group. The therapies were all lasted for two weeks for the patients in the two groups. The therapeutic effects were then evaluated by the end of therapy. Results In the treatment group, the rate of otoacoustic emission before treatment was 35%, which was increased to 70% after treatment, the rate of otoacoustic emission the control group before treatment was 45%, and the improvement to 56.7% after treatment. In the treatment group, the improvement of the passing rate of the otoacoustic emission was significantly better than that of the control group (P<0.01). Compared with the control group (P<0.05), the signal to noise ratio (SNR) of each frequency point could be improved by 0.5, 1, 2 and 8 kHz. Conclusion Shenfu Wuwei Shaoyao decoction is very effective on sudden deafness. Distortion product otoacoustic emission has important significance for the evaluation of the clinical efficacy of sudden deafness.