氨基酸对内质网应激影响的研究进展

Research progress in effects of amino acids on endoplasmic reticulum stress

内质网应激(ERS)的发生参与了人体多种疾病的发生、发展。精准、有效的干预和调控ERS成为近年来关注的热点。氨基酸作为构成人体所需蛋白质的营养元素,同时,也是人体内重要的信号传导分子。通过氨基酸对ERS反应的干预和调节很可能是一个重要且未开发的领域,有望成为探求恶性肿瘤、心血管疾病等新防治策略的潜在靶点。因此,该文将近年来氨基酸对细胞ERS反应影响的研究进展作一综述。

The occurrence of endoplasmic reticulum stress(ERS)is involved in the development of various diseases in human body.Accurate and effective intervention and regulation of ERS has become a hot spot in recent years.Amino acids are the nutrients that make up the proteins that people need,and they are also important signal transduction molecules in the human body.Intervention and regulation of ERS stress by amino acids is likely to be an important and unexplored area,and it is expected to become a potential target for new prevention strategies such as malignant tumors and cardiovascular diseases.Therefore,in this article,we will briefly review the research progress of the effects of amino acids on cellular ERS stress in recent years.