辣木叶的降糖作用及其机制研究进展

Research progress of hypoglycemic effect and mechanism of Moringa oleifera leave

辣木叶是印度传统草药,研究证明辣木叶在降低血糖、降血压、血脂,保持心血管系统健康等多方面具有显著的效果。大量的实验及临床研究均已证明辣木叶具有肯定的降糖作用,并能改善糖尿病患者肥胖,降低患者体重。对辣木叶降糖机制研究表明辣木叶可以从改善胰岛素抵抗,抑制肝脏糖异生,保护胰岛β细胞,促进胰岛素分泌,抗炎,抗氧化,调节免疫以及参与抑制小肠蔗糖酶、胰α-淀粉酶活性等多方面发挥降糖作用。辣木叶中的酚酸、黄酮、异硫氰酸酯类、绿原酸、槲皮素、鞣质、多糖等物质参与改善糖代谢。作为一种来源广、价位低的植物药,针对辣木叶降糖作用及靶点的深入研究,以及对其降糖成分的提取研发,对糖尿病的临床治疗有重要的意义和价值。

Moringa oleifera leave is a traditional Indian herbal medicine.Medical research has proved that Moringa oleifera leave has significant effect in lowering blood glucose,blood lipids,blood pressure,maintaining a healthy cardiovascular system,et al.A large number of experimental and clinical studies have demonstrated that the hypoglycemic effect of Moringa oleifera leaves is positive,and can improve the condition of the obesity of patients with diabetes,to lower their body weight.Study on the hypoglycemic mechanism of Moringa oleifera leave suggests that it has the hypoglycemic effect of insulin in many ways such as improving insulin resistance,inhibiting the liver gluconeogenesis,protecting islet beta cells,promoting insulin secretion,the function of anti-inflammatory,antioxidant,immunomodulatory,and involved in inhibiting intestinal sucrase and pancreatic amylase activity.In Moringa oleifera leaves,phenolic acids,flavonoids,isothiocyanate,chlorogenic acid,quercetin and tannin,polysaccharides and other substances were involved in the improvement of glucose metabolism.As a medicinal plant with wide source and low price,it is significant to delve deeper the hypoglycemic effect and target of Moringa oleifera leaves,and its hypoglycemic components extraction research in clinical treatment of diabetes.