Notch-1、Notch-3和Hes-1在胃癌中的表达及其临床意义

Expression and clinical significance of Notch-1,Notch-3 and Hes-1 in gastric cancer

目的探讨Notch信号通路不同受体(Notch-1、Notch-3)及下游基因Hes-1在胃癌中的表达及与临床病理参数的关系。方法选取2014—2016年中国人民解放军海军军医大学附属长征医院经病理确诊的具备完整资料的30例不同分期的胃癌标本,通过免疫组织化学染色检测Notch-1、3及Hes-1的表达,并收集患者临床病理参数进行统计分析。结果 Notch-1、3及Hes-1在胃癌不同分期中均存在表达,其中Notch-1和Hes-1阳性率在不同的T分期中差异有统计学意义(P <0.05),在中晚期患者中较高(P <0.05),进一步分析表明Hes-1和Notch-1表达有相关性(P <0.05)。Notch-3的表达在不同年龄中有差异(P <0.05)外,在其他临床病理参数中均无差异。结论 Notch信号通路中Notch-1、3及Hes-1在胃癌患者不同临床病理参数中的表达存在一定差异,未来仍需进一步研究。

Objective To determine the expression of Notch receptors(Notch-1&3)and the downstream gene Hes-1 in gastric cancer and potential clinical significance.Methods Thirty gastric cancer patients enrolled in Shanghai Changzheng Hospital during 2014 to 2016 were involved in this study.Clinical-pathological parameters were collected,and expression of Notch-1&3 and Hes-1 were measured by immunohistochemical staining.Results Notch-1&3 and Hes-1 were heterogeneously expressed in the patients with different stage while patients with advanced stage of tumor experienced increased levels of Notch-1 and Hes-1(P<0.05).Expression of Hes-1 was positively correlated with Notch-1(P<0.05).However,expression of Notch-3 was not affect by all clinical parameters except ages(P<0.05).Conclusions Expression of Notch-1&3 and Hes-1 is likely to be affected in gastric cancer patients,and additional studies are necessary.