胆汁淤积导致肝纤维化的机制及其阻断策略

Pathogenesis of cholestasis-induced liver fibrosis and thoughts for blockade

胆汁淤积是指胆汁流形成、分泌和排泄障碍的一种病理状态,而肝纤维化是肝损伤引起的组织修复过程。胆汁淤积性肝病是由胆汁淤积、胆管渐进性破坏和肝内炎症持续存在所导致的一种慢性肝病,引起胆管细胞和肝细胞损伤,并逐步进展为肝纤维化。结合目前的研究进展,对胆汁淤积导致肝纤维化的发生机制和阻断策略作一综述。

Cholestasis refers to a pathological state of disorders in the formation,secretion,and excretion of bile flow,and liver fibrosis is a process of tissue repair induced by liver injury.Cholestatic liver disease is a chronic liver disease caused by cholestasis,progressive bile duct injury,and persistent intrahepatic inflammation,and it may cause cholangiocyte and hepatocyte injury,which will gradually progress to liver fibrosis.With reference to the current research advances,this article reviews the pathogenesis of cholestasis-induced liver fibrosis and the strategies for blockade.