Rab25在肿瘤转移中的研究进展

Research progress of Rab25 in tumor metastasis

转移是影响肿瘤患者生存和死亡的主要原因,近年来研究发现,Rab25与肿瘤侵袭转移密切相关。Rab25在肿瘤转移中具有双重特性,可作为致癌基因或抑癌基因,在大多数肿瘤类型中,Rab25作为致癌基因,仅在少数肿瘤中,Rab25表现出肿瘤抑制功能,然而Rab25双重作用机制及信号通路尚不明确。文章主要就Rab25在肿瘤转移中作用的相关研究进行综述。

Metastasis is the main reason that affects the survival and death of cancer patients.In recent years,it has been found that Rab25 is closely related to tumor invasion and metastasis.Rab25 has dual role in tumor metastasis,which can be used as oncogene or tumor suppressor gene.In most tumor types,Rab25 is an oncogene,and only in a few tumors,Rab25 shows tumor suppressor function.However,the dual action mechanism and signal pathway of Rab25 are not very clear.This article summarizes the related research on the role of Rab25 in tumor metastasis.