微创小切口手术对早期胸中下段食管癌患者的治疗效果及对其疼痛的影响

Therapeutic effect of minimally invasive small incision surgery on patients with early thoracic esophageal cancer and its influence in pain

目的探究微创小切口手术对早期胸中下段食管癌患者的治疗效果及对其疼痛的影响。方法选取2016年3月—2017年3月在我院接受治疗的早期胸中下段食管癌患者160例,随机分为常规手术组和微创小切口手术组各80例,常规手术组患者使用常规手术治疗,微创小切口手术组患者使用微创小切口手术治疗。对肺活量(Vital capacity,VC)、一秒用力呼气容积(Forced expiratory volume 1,FEV1)检测、视觉模拟评分法(Visual analogue scale,VAS)、住院时间、手术时间及术中出血量进行统计,酶联免疫法检测应激激素如生长激素(Growth hormone,GH)、皮质醇(Cortisol,Cor)、白介素-8(Inter-leukin-8,IL-8)水平,并对两组患者不良反应发生情况进行统计。结果微创小切口手术组VC、FEV1水平显著高于常规手术组,出血量、手术时间、及住院时间短于常规手术组,GH、Cor水平、VAS评分、不良反应发生率低于常规手术组,IL-8高于常规手术组,差异均具有统计学意义(P <0. 05)。结论微创小切口手术治疗早期胸中下段食管癌效果显著,能够缓解患者疼痛,减少不良反应。

Objective The aim of this study was to explore the effect of minimally invasive small incision surgery on early thoracic esophageal cancer patients and its impact on pain.Methods A total of 160 patients with early thoracic esophageal cancer who were treated in our hospital from March 2016 to March 2017 were randomly divided into the conventional surgery group and the minimally invasive small incision surgery group.Patients in the conventional surgery group were treated with routine operation,and patients in the minimally invasive small incision surgery group were treated with minimally invasive small incision surgery.Vital capacity(VC),forced expiratory volume 1(FEV1),visual analogue scale(VAS),hospitalization time,operation time and intraoperative bleeding volume were counted.Growth hormone(GH)was detected by ELISA.The levels of cortisol(Cor)and interleukin-8(IL-8)were measured by immunoassay and adverse reactions.Results The levels of VC and FEV1 in the minimally invasive small incision group were significantly higher than those in the conventional surgery group.The bleeding volume,operation time and hospitalization time were shorter than those in the conventional surgery group.The levels of GH and Cor,VAS score and incidence of adverse reaction rate were lower than those in the conventional surgery group,and the level of IL-8 was also higher in than that in the conventional surgery group.The difference was statistically significant(P<0.05).Conclusion Minimally invasive small incision surgery is effective on the treatment of early thoracic esophageal cancer,relieving pain and reducing adverse reactions.