定量脑电图在健康人群中的应用研究

An applied research of quantitative electroencephalography in healthy population

目的:探讨定量脑电图在健康人群应用的意义,为早期发现脑功能异常提供有价值的客观依据。方法:对73例健康成人(分为偶饮酒组及不饮酒组)进行定量脑电图功率谱分析,记录安静闭目状态下的19导脑电信号,经快速傅里叶变换分别计算:(1)δ波、θ波、α波、β波和γ波等各频段的绝对值和相对值;(2)各波段每Hz的绝对值和相对值;(3)各频段(δ/θ、δ/α、δ/β、δ/高β、θ/α、θ/β、θ/高β、α/β、α/高β、β/高β)的比值;并将上述各项指标与纽约大学医学院的正常人脑电信号库做比对。结果:偶饮酒组β、β1、β2、β3和高β频段绝对功率分别在P4、T3、T6;P4、01、T4、T6;T3、T6;F3、F4、C3、C4、T3、T6和C3、C4、P4、T6、Pz导联显著低于健康组(P<0.05),γ频段在FP2、F4和Fz导联显著低于健康组(P<0.05)。偶饮酒组α1频段相对功率在FPl、FP2、F3、F4、C3、C4、P3、P4、01、02、F7、T3、T5、T6、Cz、Fz导联显著高于健康组,差异有统计学意义(P<0.05);α2频段相对功率在F3、F4、C4、F8、T6、Cz、Fz导联带显著低于对照组,差异有统计学意义(P<0.05)。偶饮酒组每Hz绝对值除β、β1、β2、β3和高β波在各脑区显著低于健康组(P<0.05)外,δ波频段在F3导联、γ2波频段在F8和FP2导联、α波频段在T6导联显著低于健康组(P<0.05);每Hz相对值γ2和高γ波频段F8导联显著低于健康组(P<0.05)。健康组与偶饮酒组各频段比值比较差异无统计学意义。偶饮组12例β/高βZ值≥3,健康组2例Z值≥3,差异有统计学意义(P<0.05)。结论:偶饮酒者定量脑电图指标与健康人群显著不同,定量脑电图功率谱分析有助于早期发现健康人群脑功能异常。

Objective:Discussed quantitative electroencephalography (qEEG) utility value in healthy population. Applied an objective basis for early detection of brain dysfunction. Methods:Total 28 occasional drinkers and as control group, 45 normal adults qEEGs were analyzed. Resting-state qEEG during eyes closed was acquired by using 19-electrodes system. Data including:①the absolute power and relative power of δ,θ,α,β,γ;② the absolute power and the relative power of each frequency band per Hertz; 3) the ratio of δ/θ,δ/α,θ/β,δ/high β,θ/α,θ/β,θ/high β,α/β,α/high β and β/high β, which were calculated based on Fast Fourier Transform (FFT). All above data was compared with qEEGs database of New York Medical University School of Medicine. Results:The absolute frequency power of β band (in P4, T3, T6 electrodes),β1 band (in P4, 01, T4, T6 electrodes),β2 band (in T3, T6 electrodes),β3 band (in F3, F4, C3, C4, T3, T6 electrodes), high β band (in C3, C4, P4, T6, Pz electrodes) and γ band (in FP2, F4, Fz electrodes) were significantly lower in occasional drinkers than normal population ( P <0.05). Comparing with normal population, the relative α1 band power in FPl, FP2, F3, F4, C3, C4, P3, P4, 01, 02, F7, T3, T5, T6, Cz, Fz electrodes were significantly higher and the relative α2 band power in F3, F4, C4, F8, T6, Cz, Fz electrodes were significantly lower in occasional drinkers( P <0.05). The absolute power per Hz in β,β1,β2,β3 and high β bands of whole areas were significantly lower in occasional drinkers group than normal population, as well as δ band in F3,γ2 band in F8 and FP2, and α band in T6( P <0.05). The relative power per Hz of γ2 band and high γ band in F8 were significantly lower in occasional drinkers than healthy population ( P <0.05). No significant differences in each band power ratio between two groups.β/high β Z score≥3 were different obviously in occasional drinkers group (12 cases) comparing with normal population (2 cases)( P <0.05). Conclusion:The qEEG indices are significantly different between occasional drinkers and healthy population, and qEEG frequency band analysis is helpful for the early detection of brain dysfunction in healthy subjects.