炎症性肠病肠上皮细胞修复机制的研究进展

Research progress on repair mechanism of intestinal epithelial cells in inflammatory bowel disease

肠上皮细胞及其之间的紧密连接是肠黏膜屏障的重要组成部分。炎症性肠病中可出现肠上皮屏障的损伤,会导致肠黏膜的反复受损和修复。上皮损伤的修复取决于附近上皮细胞的迁移、增殖和分化。多种生长因子、细胞因子、三叶因子参与了调节肠道上皮损伤的修复,近年来还发现固有免疫中的Toll样受体和NOD样受体对维持肠内稳态和肠黏膜修复也起着重要作用。

Intestinal epithelial cells and tight intercellular junction are important components of intestinal mucosal barrier. The epithelial barrier damage may occur in inflammatory bowel disease, which leads to recurrent injury and repair of the intestinal mucosa. The process of epithelial injury repair relies upon the migration, proliferation and differentiation of adjacent epithelial cells. Multiple growth factors, cytokines and trefoil factors participate in regulating the process of intestinal epithelial injury repair. In recent years, toll-like receptors and NOD-like receptors in innate immunity have also been found to play a pivotal role in maintaining intestinal homeostasis and intestinal mucosal repair.