NPY/AgRP与肥胖及其相关疾病研究进展

Research progress on association between NPY/AgRP and obesity and related diseases

全球超重及肥胖症患者超过14亿,在发达国家中该人群数量更是翻倍。自1980年以来,发展中国家超重及肥胖症患者人数较此前增加了3倍。肥胖与许多疾病密切相关,包括糖尿病、脑卒中和某些类型的癌症。研究表明肥胖患者每年医疗费用比体型正常者多出约42%。控制肥胖已迫在眉睫。近年来,许多国内外学者发现神经肽是调节食欲的关键信号分子。该文将着重阐述神经肽中的神经肽Y/刺鼠相关蛋白与肥胖及其相关疾病的研究进展。

More than 1.4 billion of people are classified as overweight and obese patients across the world, and the number of such patients has been doubled in developed countries. Since 1980, the number of overweight and obesity patients has been increased threefold in developing countries. Obesity is closely related to multiple diseases, such as diabetes mellitus, stroke and certain types of cancer. Previous research has demonstrated that the medical expanse of obese patients is approximately 42% more on that of their counterparts with normal weight. Control of obesity is an imminent task. Recently, many scholars at home and abroad have found that neuropeptide is a key signal molecule to regulate the appetite. In this article, the research progress on the correlation between neuropeptide Y /Agouti-related protein, obesity and related diseases was summarized.