摘要
为得到分散性和稳定性较好的聚多巴胺纳米粒子,利用"沉淀-再分散法"高效制备了聚多巴胺纳米粒子水分散液。首先利用溶液氧化法制备了分散在水/乙醇中的聚多巴胺纳米粒子,然后向分散液中加入丙酮使聚多巴胺纳米粒子絮凝。收集沉降物,用丙酮冲洗并干燥后,加水重新分散得到纯化的聚多巴胺纳米粒子水分散液。丙酮沉淀法得到的聚多巴胺纳米粒子形貌规整,分散性好,粒径分布在250 nm左右,在水中具有良好的储存稳定性和光热性能,与传统的超速离心提纯法相比,产率可提高57. 4%。此方法为其之后在药物载体及光热治疗等方面的应用研究提供了便利。
In order to obtain dispersive and stable polydopamine nanoparticles, an aqueous dispersion of polydopamine nanoparticles was efficiently prepared using the “precipitation-redispersion” method. First, polydopamine nanoparticles dispersed in water/ethanol were prepared by a solution oxidation method, and then acetone was added to the dispersion to flocculate the polydopamine nanoparticles. The precipitate was collected , rinsed with acetone and dried, and then redispersed in water to obtain a purified aqueous dispersion of polydopamine nanoparticles. The polydopamine nanoparticles obtained by the acetone precipitation method are regular in shape with good dispersibility. The particle size distribution is about 250 nm, and has good storage stability and photothermal properties in water. Compared with conventional ultracentrifugation purification method, the yield increases by 57.4%. This method is essential for further applications in drug delivery and photothermal therapy.
作者
王贺
罗静
李小杰
施冬健
陈明清
WANG He;LUO Jing;LI Xiaojie;SHI Dongjian;CHEN Mingqing(Key Laboratory of Synthetic and Biological Colloids,Ministry of Education,School of Chemical and Material Engineering,Jiangnan University,Wuxi,Jiangsu 214122,China)
出处
《应用化学》
CAS
CSCD
北大核心
2019年第2期155-160,共6页
Chinese Journal of Applied Chemistry
基金
中央高校基本科研业务费专项资金资助(JUSRP115A07)
江苏省博士后科研资助计划(1601237C)
江南大学合成与生物胶体教育部重点实验室开放课题(JDSJ2016-06)资助~~
关键词
聚多巴胺纳米粒子
沉淀法
提纯
polydopamine nanoparticles
precipitation method
purification