缺血修饰清蛋白在糖尿病肾病早期诊断中的应用

Application of ischemia-modified albumin in early diagnosis of diabetic nephropathy

目的探讨血清缺血修饰清蛋白(IMA)在糖尿病肾病诊断中的作用。方法收集175例糖尿病患者标本和临床资料,分为单纯糖尿病组(116例)和糖尿病肾病组(59例)。另抽取155例健康体检者作为对照组。检测各组IMA、24h尿清蛋白等指标,分析各组IMA的差异及与其他指标的相关性,以及IMA对糖尿病肾病的检出率。结果糖尿病肾病组的IMA值与其他两组的差异有统计学意义(P<0.05)。IMA、IMA指数均与24h尿清蛋白呈负相关(r=-0.216、-0.256,P<0.05);IMA对糖尿病肾病的检出率与24h尿清蛋白的检出率差异有统计学意义(P<0.05);IMA、糖化血红蛋白(HbA1c)、三酰甘油(TG)联合检测糖尿病肾病与24h尿清蛋白的检出率差异无统计学意义(P>0.05)。结论糖尿病肾病患者的IMA有所升高,IMA联合HbA1c、TG检测对糖尿病肾病的早期诊断有重要意义。

Objective To explore the role of serum ischemia-modified albumin(IMA)in the diagnosis of diabetic nephropathy(DN).Methods The samples and clinical data of 175 patients with diabetes mellitus(DM)were collected and divided into the diabetic group(n=116)and DN group(n=59).Other 155 healthy subjects undergoing physical examination were selected as the control group.The levels of IMA,24 h urinary and other indicators were measured in each group.The difference of IMA level in each group and its correlation with other indicators were analyzed.The detection rate of IMA in DN was analyzed.Results The IMA level had statistical difference between the DN group and other two groups,and the difference was statistically significant(P<0.05).The IMA and IMA indexes were negatively correlated with urinary albumin(r=-0.216,r=-0.256,P<0.05);the DN detection rate had difference between IMA and 24 h urinary albumin;the detection rate for DN had no difference between the IMA,HbA1c and TG combined detection with 24 h urinary albumin.Conclusion The IMA level in the patients with DN is elevated,and the detection of IMA combined with HbA1c and TG has an important significance for the early diagnosis of DN.