大庆市城区部分居民血清维生素D水平评估

Vitamin D status of Daqing urban residents

目的了解大庆市居民血清维生素D水平,为骨质疏松症(osteoporosis,OP)防治提供依据。方法 2014年3月至2016年4月招募大庆市城区居民4874名,其中0～10岁864人,11～20岁298人,21～30岁155人,31～40岁580人,41～50岁888人,51～60岁927人,61～70岁750人,70岁以上412人。采集受试者清晨空腹静脉血,应用酶联免疫法测定血清25-羟基维生素D[25 hydroxy vitamin D,25(OH)D]浓度。以血清25(OH)D<30 nmol/L为维生素D缺乏;血清25(OH)D在30～49.9 nmol/L之间为维生素D不足;血清25(OH)D≥50 nmol/L为维生素D充足。评估大庆城区居民血清维生素D水平。结果大庆城区部分居民血清25(OH)D平均水平为(16.89±11.92)nmol/L,0～10岁组血清25(OH)D平均水平为(27.44±14.90) nmol/L;11～20岁组血清25(OH)D平均水平为(13.86±8.51)nmol/L;21～30岁组血清25(OH)D平均水平为(15.40±13.41) nmol/L;31～40岁组血清25(OH)D平均水平为(17.57±12.31) nmol/L;41～50岁组血清25(OH)D平均水平为(13.01±8.08)nmol/L;51～60岁组血清25(OH)D平均水平为(14.31±9.20)nmol/L;61～70岁组血清25(OH)D平均水平为(14.94±9.33)nmol/L;70岁以上组血清25(OH)D平均水平为(14.32±9.58)nmol/L。不同年龄组相比较(完全随机方差分析one way ANOVA检验),差异有统计意义(F=152.67,P<0.01)。经独立样本t检验,不同性别间差异有统计意义(t=3.05,P=0.002),男性高于女性。结论大庆市部分居民普遍存在维生素D缺乏,女性维生素D水平低于男性。

Objective To assess vitamin D status in Daqing urban residents by two kinds of standards,and to provide a basis for the prevention and treatment of osteoporosis(OP).Methods A total of 4874 people aged from 0 to 75 years in Daqing urban area were enrolled in this cross-sectional study from March 2014 to April 2016.864(17.7%)of them aged between 0-10 years,298(6.1%)between 11-20 years,155(3.2%)between 21-30 years,580(11.9%)between 31-40 years,888(18.2%)between 41-50 years,927(19.0%)between 51-60 years,750(15.4%)between 61-70 years,and 412(19.0%)over 70 years.Serum 25-(OH)D level was tested using ELISA.① Vitamin D deficiency was defined as serum 25-(OH)D<30 nmol/L;②Vitamin D insufficiency was defined as serum 25-(OH)D 30-49.9 nmol/L;③Vitamin D sufficiency was defined as serum 25-(OH)D≥50 nmol/L.We evaluated the vitamin D status of the residents in Daqing urban area.Results Serum 25-(OH)D average level of these residents in Daqing city was(16.89±11.92)nmol/L,0-10 years group was(27.44±14.90)nmol/L;11-20 years(13.86±8.51)nmol/L;21-30 years(15.40±13.41)nmol/L;31-40 years(17.57±12.31)nmol/L;41-50 years(13.01±8.08)nmol/L;51-60years(14.31±9.20)nmol/L;61-70 years(14.94±9.33)nmol/L;over 70 years(14.33±9.58)nmol/L.We compared different age groups(complete random variance analysis one way ANOVA,F=152.67,P<0.001),and the differences were statistically significant.In the two independent sample t test,the difference between males and females was statistically significant(t=3.05,P=0.002),and men had higher levels than women.Conclusion The prevalence of vitamin D insufficiency or deficiency in Daqing urban residents was common,the level of vitamin D in women were lower than that of men.