血液透析滤过联合血液透析治疗慢性肾功能衰竭的效果观察

Effect of Hemodiafiltration Combined with Hemodialysis on Chronic Renal Failure

目的观察血液透析滤过联合血液透析治疗慢性肾衰的效果。方法选择2017年6月～2018年6月在天津北大医疗海洋石油医院接受治疗的慢性肾功能衰竭患者70例,随机分为对照组和观察组,各35例。对照组仅接受血液透析治疗,观察组在此基础上加用血液透析滤过治疗。观察两组治疗前后血尿素氮(BUN)、血清肌酐(SCr)与肾小球过滤(GFR)变化水平,记录两组患者白细胞介素-8(IL-8)、白细胞介素-6(IL-6)与血清超敏C反应蛋白(hs-CRP)水平。结果治疗后,观察患者BUN(6.07±1.31)mmol/L、SCr(117.09±10.99)μmol/L及GFR(121.49±12.25)ml/min均低于对照组的(8.36±1.24)mmol/L、(235.57±10.76)μmol/L、(140.83±12.18)ml/min,差异有统计学意义(P<0.05);观察组IL-8、IL-6与hs-CRP水平均低于对照组,差异有统计学意义(P<0.05)。结论在慢性肾衰竭患者治疗中联合应用血液透析滤过、血液透析治疗,有助于清除患者血液中有害物质以改善肾功能,减轻机体炎症反应,进而改善患者临床症状。

Objective To observe the effect of hemodiafiltration combined with hemodialysis on chronic renal failure.Methods 70 patients with chronic renal failure who were treated at Tianjin Beida Medical Offshore Oil Hospital from June 2017 to June 2018 were randomly divided into control group and observation group,35 cases each.The control group received only hemodialysis treatment,and the observation group was treated with hemodiafiltration.The levels of blood urea nitrogen(BUN),serum creatinine(SCr)and glomerular filtration(GFR)were observed before and after treatment.The two groups were recorded for interleukin-8(IL-8)and interleukin-6(IL-6)Serum hypersensitive C-reactive protein(hs-CRP)levels.Results After treatment,patients with BUN(6.07±1.31)mmol/L,SCr(117.09±10.99)μmol/L and GFR(121.49±12.25)ml/min were lower than the control group(8.36±1.24)mmol/L,(235.57±10.76)μmol/L,(140.83±12.18)ml/min,the difference was statistically significant(P<0.05);the IL-8,IL-6 and hs-CRP levels in the observation group were lower than the control group,the difference statistically significant(P<0.05).Conclusion Combined use of hemodiafiltration and hemodialysis in the treatment of patients with chronic renal failure can help remove harmful substances in the blood of patients to improve renal function,reduce the body's inflammatory response,and improve the clinical symptoms of patients.