马来酸吡咯替尼对乳腺癌术后患者心脏功能的影响

Effect of Pyrrolidine Maleate on Cardiac Function in Patients after Breast Cancer Operation

目的探讨3年生存乳腺癌患者服用马来酸吡咯替尼对双心室功能的影响。方法选择2013年2月～2018年6月在我院接受马来酸吡咯替尼治疗的45例女性乳腺癌患者作为观察组,选择同期40例健康志愿者作为对照组,检测观察组患者服药前后二尖瓣侧壁瓣环、间隔瓣环及右室侧壁瓣环舒张期运动速度,右室侧壁瓣环M型运动幅度、左心室射血分数以及左室整体长轴峰值应变,同时与对照组相关指标进行对比。结果与对照组和用药前比较,用药后观察组患者左心室二尖瓣侧壁瓣环、间隔瓣环、右室侧壁瓣环舒张期运动速度及左室整体长轴峰值应变均明显减低,差异有统计学意义(P<0.05);但观察组患者左心室、右心室收缩功能与对照组比较无明显变化,差异无统计学意义(P>0.05)。结论长期服用马来酸吡咯替尼的乳腺癌患者左心室、右心室收缩功能无明显变化,但双心室舒张功能均降低,提示该类药物可能损害心肌功能。

Objective To investigate the effect of pyrrolidine maleate on the function of double ventricle in patients with breast cancer who survived for 3 years.Methods From February 2013 to June 2018,45 female breast cancer patients who received pyrrolidine maleate in our hospital were selected as observation group.40 healthy volunteers were selected as the control group.Mitral valve sidewall annulus,spacer annulus,and right ventricular sidewall annulus diastolic velocity,right ventricular sidewall annulus M-mode amplitude,left ventricular ejection fraction,and left ventricular global long-axis peak strain,and the relevant indicators of the control group were compared.Results Compared with the control group and before administration,the left ventricular mitral valve sidewall annulus,septum annulus,right ventricular sidewall annulus diastolic velocity and left ventricular total long axis peak strain were significantly reduced in the observation group,the difference was statistically significant(P<0.05).However,there was no significant difference in left ventricular and right ventricular systolic function between the observation group and the control group(P>0.05).Conclusion There is no significant change in left ventricular and right ventricular systolic function in breast cancer patients taking pyrrolidine maleate for a long time,but the diastolic function of both ventricles is decreased,suggesting that this drug may impair myocardial function.