大剂量艾司奥美拉唑镁对幽门螺杆菌相关性胃炎的治疗效果分析

Effect analysis of high dose Esomeprazole magnesium in the treatment of Helicobacter pylori related gastritis

目的探讨大剂量艾司奥美拉唑镁治疗幽门螺杆菌相关性胃炎的临床效果。方法选择2016年6月至2017年5月于本院就诊的幽门螺杆菌相关性胃炎患者120例为研究对象,根据艾司奥美拉唑镁治疗剂量不同将其分为高剂量组(62例)和标准剂量组(58例),高剂量组患者予以40 mg艾司奥美拉唑镁肠溶片,2次/d;标准剂量组患者予以20 mg艾司奥美拉唑镁肠溶片,2次/d;两组疗程均为2周,比较两组患者治疗后的临床效果及临床症状改善情况。随访6个月,比较两组患者幽门螺杆菌清除率、复发率及不良反应发生率。结果高剂量组患者治疗总有效率显著高于标准剂量组(P <0.05);治疗后,高剂量组患者临床症状改善情况显著优于标准剂量组(P <0.05),幽门螺杆菌清除率显著高于标准剂量组(P <0.05),复发率显著低于标准剂量组(P <0.05)。两组患者不良反应发生率无显著差异(P> 0.05)。结论大剂量艾司奥美拉唑镁可显著改善幽门螺杆菌相关性胃炎患者的临床症状,提高幽门螺杆菌清除率,降低不良反应发生率,值得临床推广。

Objective To investigate the clinical effect of high dose Esomeprazole magnesium in the treatment of Helicobacter pylori related gastritis.Method 120 patients with Helicobacter pylori related gastritis who were admitted to our hospital from June 2016 to May 2017 were selected as the study subjects.According to the different doses of Esomeprazole magnesium,they were randomly divided into high-dose group(62 cases)and standard dose group(58 cases).Patients in high-dose group were given 40 mg Esomeprazole magnesium twice a day.Patients in standard dose group were given 20 mg Esomeprazole magnesium twice a day;both groups patients were treated for 2 weeks,the clinical effect and improvement of clinical symptoms were compared between the two groups.Patients were followed up for 6 months to compare the Helicobacter pylori clearance rate,recurrence rate and incidence of adverse reactions between the two groups.Result The total effective rate in high-dose group was significantly higher than that in standard dose group(P<0.05).After treatment,the improvement of clinical symptoms in high-dose group was significantly better than that in standard dose group(P<0.05),the clearance rate of Helicobacter pylori was significantly higher than that in standard dose group(P<0.05),and the recurrence rate was significantly lower than that in standard dose group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion High dose of Esomeprazole magnesium can significantly improve the clinical symptoms of patients with Helicobacter pylori related gastritis,improve the clearance rate of Helicobacter pylori,and reduce adverse reactions,which is worthy of clinical promotion.