低剂量索他洛尔与普罗帕酮治疗心律不齐的临床效果观察

Observation on the Clinical Effect of Low Dose Sotalol and Proparone in the Treatment of Arrhythmia

目的探讨与分析低剂量索他洛尔与普罗帕酮在心律不齐临床治疗中的应用效果及安全性。方法选取本院2016年9月—2017年9月接收的56例心律不齐患者,按照入院顺序奇偶排序分为两组,各28例,观察组行低剂量索他洛尔治疗,对照组行普罗帕酮治疗。对比两组患者治疗效果,并观察两组患者治疗后不良反应发生情况以及QT间期离散度(QTd)情况。结果观察组总有效率及不良反应与对照组相比,差异无统计学意义(P> 0.05)。观察组患者治疗后QTd改善情况显著优于对照组,差异有统计学意义(P <0.05)。结论低剂量索他洛尔与普罗帕酮治疗心律不齐效果及安全性均相当,但低剂量索他洛尔对于患者的QTd改善情况更为显著。

Objective To investigate and analyze the efficacy and safety of low-dose sotalol and propafenone in the clinical treatment of arrhythmia.Methods 56 cases of patients with arrhythmia and who received in our hospital from September 2016 to September 2017 were divided into two groups according to the order of admission,with 28 in each group.The observation group was treated with low-dose sotalol,while the control group was treated with propafenone.Then,the therapeutic effects of the two groups were compared,and the occurrence of adverse reactions and the dispersion of QT interval(QTd)of the two groups were observed.Results There was no significant difference in the effective rate and adverse reactions between the observation group and the control group(P >0.05).After treatment,the improvement of QTd in the observation group was significantly better than that in the control group,the difference was statistically significant(P<0.05).Conclusion The low dose sotalol and propafenone have the same efficacy and safety in the treatment of arrhythmia,but low dose sotalol has more significant improvement in patients'QTd.