中医治疗盆腔炎的用药规律

Medication rules of traditional Chinese medicine for treating pelvic inflammatory disease

目的探讨中医治疗盆腔炎的用药规律。方法收集治疗盆腔炎的中药处方400付,分析处方中各种药物的使用频次。对使用频次≥100次的药物进行主特征值分析、聚类分析及主成分分析。结果使用频次≥100次的29味药物中,位于前5位的药物为路路通、延胡索、忍冬藤、乌药、皂角刺,有9味药主成分的特征值> 1,且其累积贡献率达88. 45%。这29味中药可聚类分为5类,第1类药物为乌药、泽兰、皂角刺、川芎、桂枝、延胡索,第2类药物为木香、枳壳,第3类药物为当归、苏木,第4类药物为地龙、土鳖虫、川楝子、败酱草、赤芍、丹参、白芍、柴胡、香附、续断、路路通、牛膝、熟地黄、鸡血藤、生地黄,第5类药物为桃仁、大血藤、丝瓜络、忍冬藤。主成分分析与聚类分析的结果基本保持一致。结论中医治疗盆腔炎的用药具有一定规律且主要药物使用合理,可指导临床合理用药。

Objective To explore the medication rules of traditional Chinese medicine for treating pelvic inflammatory disease.Methods Four hundreds herbs prescriptions for treating pelvic inflammation were collected,and the use frequency of each herb in the prescriptions was analyzed.Principal eigenvalue analysis,cluster analysis and principal component analysis were performed in the herbs with the use frequency≥100 times.Results Of 29 drugs with the use frequency≥100 times,the top 5 herbs were in the sequence of fructus liquidambaris,rhizoma corydalis,caulis lonicerae,combined spicebush root and spina gleditsiae,and there were 9 herbs whose eigenvalues of main components were >1 with the cumulative contribution rate reaching 88.45%.These 29 herbs could be clustered into 5 kinds:the first kind of herbs included combined spicebush root,herba lycopi,spina gleditsiae,rhizoma chuanxiong,cassia twig and rhizoma corydalis;the second kind of herbs included radices saussureae and fructus aurantii;the third kind of herbs included Chinese angelica and sappan lignum;the forth kind of herbs included pberetima,ground beetle,fructus meliae toosendan,herba patriniae,radix paeoniae rubra,salvia miltrorrhiza,radices paeoniae alba,radix bupleuri,rhizoma cyperi,radix dipsaci,fructus liquidambaris,radix achyranthis bidentatae,rehmanniae radix praeparata,lignum millettiae and radix rehmanniae recens;and the fifth kind of herbs included peach seed,sargentodoxa cuneata,retinervus luffae fructus and caulis lonicerae.The results of principal component analysis were consistent with those of cluster analysis.Conclusion The medication of traditional Chinese medicine for treating pelvic inflammatory disease possesses certain rules and the administrations of the main herbs are reasonable,which can provide guidance for rational drug use clinically.