修净胶囊辅助降血脂功能的研究

Auxiliary Hypolipidemic Effect of Xiujing Capsules on Hyperlipidemia in Rats

目的研究修净胶囊的辅助降血脂功能。方法采用混合型高脂血症动物模型,SD大鼠按体重随机分为模型组(40只)和空白对照组(10只),模型组给予高脂饲料,空白组给予维持饲料,7天后将模型组大鼠根据血清总胆固醇水平随机分为模型对照组和修净胶囊低、中、高(0.2,0.4,0.8 g/kg)3个剂量组,每组10只。修净胶囊各剂量组灌胃给予相应剂量的受试样品30 d,模型对照和空白对照灌胃给予等容积的溶媒。第31天取血检测血清甘油三酯(TG),总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平。结果与模型对照组比较,0.8 g/kg剂量组大鼠血清TG和血清TC均显著降低(P<0.05或P<0.01),0.4和0.8 g/kg剂量组LDL-C显著降低(P<0.05或P<0.01),3个剂量组血清HDL-C无明显变化。结论修净胶囊具有辅助降血脂功能。

Objective To explore the auxiliary hypolipidemic action of Xiujing Capsules. Methods SD rats were randomly divided into model group (40 rats) and blank control group (10 rats). The rats in model group were given high fat diet and the rats in blank group were given the normal feed. After 7 days, the rats in the model group were randomly divided into model control group and low, medium and high (0.2, 0.4, 0.8 g/kg) dose groups of Xiujing Capsules according to the level of total cholesterol, 10 rats in each group. Animals in Xiujing Capsules treated groups were given corresponding doses of the samples by gavage for 30 days, and the animals in the model control group and the blank control group were given corresponding amount of solvent. The levels of serum triglyceride (TG), total cholesterol (TC), low density lipoproteincholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were measured on day 31. Results Compared with model control group, the levels of serum TG and TC were significantly lower in the 0.8 g/kg dose group (P<0.01 or P<0.05), and the level of serum LDL-C was significantly lower in the 0.4 and 0.8 g/kg dose group (P<0.01 or P<0.05), while the the levels of serum HDL-C in 3 Xiujing Capsules treated groups showed no obvious change (P >0.05). Conclusion Xiujing Capsules have auxiliary hypolipidemic effect.