前列地尔治疗慢性肾功能衰竭的临床效果

Clinical effect of Alprostadil in the treatment of chronic renal failure

目的研究前列地尔治疗慢性肾功能衰竭的临床效果。方法选取2016年12月～2017年12月我院收治的66例慢性肾功能衰竭患者作为研究对象,按照奇偶分组法将其分为对照组(33例)与实验组(33例)。对照组患者采用常规药物治疗,实验组患者采用前列地尔治疗。比较两组患者的治疗效果、治疗前后肾功能指标、24 h尿蛋白量、治疗前后的血液流变学指标变化。结果经过药物治疗14 d后,实验组患者的治疗总有效率为81.82%,高于对照组(63.64%),差异有统计学意义(P<0.05);实验组患者治疗后的血尿素氮(BUN)、血肌酐(SCr)等肾功能指标和24 h尿蛋白量低于治疗前,内生肌酐清除率(Ccr)高于治疗前,差异有统计学意义(P<0.05);实验组患者治疗后的BUN、SCr、等肾功能指标和24 h尿蛋白量低于对照组,Ccr高于对照组,差异有统计学意义(P<0.05);实验组患者治疗后的全血低切黏度、全血高切黏度、血细胞聚集指数、血液黏度、血细胞比容和红细胞变形指数等血液流变学指标低于治疗前,差异有统计学意义(P<0.05);实验组患者治疗后的全血低切黏度、全血高切黏度、血细胞聚集指数、血液黏度、血细胞比容和红细胞变形指数等血液流变学指标低于对照组,差异有统计学意义(P<0.05)。结论慢性肾功能衰竭患者接受前列地尔治疗,能够改善患者的肾功能和血液流变学指标,值得推广应用。

Objective To study the clinical effect of Alprostadil in the treatment of chronic renal failure(CRF).Methods Sixty-six patients with CRF admitted from December 2016 to December 2017 were enrolled as study subjects.The participants were divided into control group(n=33)and experimental group(n=33)according to the odd or even number.In the control group,conventional drug was used,while in the experimental group,Alprostadil was adopted.The therapeutic effect,renal function indicators before and after treatment,24 h urine protein,blood rheology indicators before and after treatment were compared in the two groups.Results After 14-day drug treatment,the total therapeutic effectiveness rate of the experimental group was 81.82%,which was higher than that of control group(63.64%)with a significant difference(P<0.05).The renal function indicators such as blood urea nitrogen(BUN),serum creatinine(SCr)and 24 h urine protein after treatment in the experimental group were all lower compared with those before treatment,creatinine clearance rate(Ccr)was higher compared with before treament with significant differences(P<0.05).The renal function indicators such as BUN,SCr and 24 h urine protein after treatment in the experimental group were lower compared with those of the control group,Ccr was higher than that in the control group with statistical significance(P<0.05).The blood rheology indicators such as the whole blood low-shear viscosity,whole blood high-shear viscosity,blood cell aggregation index,blood viscosity,haematocrit,erythrocyte deformation index after treatment in the experimental group were lower compared with those before treatment(P<0.05).The above-mentioned blood rheology indicators in the experimental group after treatment were lower compared with those in the control group with statistical significance(P<0.05).Conclusion The treatment of Alprostadil in patients with CRF can improve patient′s renal function and hemorheology indicators,which is worthy of promotion and application.