康复新液联合奥美拉唑治疗非幽门螺杆菌感染消化性溃疡的临床效果

Clinical effects of application of Rehabilitation New Liquid combined with Omeprazole in treatment of non-Helicobacter pylori infection peptic ulcer

目的探讨康复新液联合奥美拉唑治疗消化性溃疡的临床效果。方法选取2017年1月～2018年4月九江学院附属医院收治的84例符合要求的消化性溃疡患者作为研究对象,将其随机分为病例组和对照组,每组各42例。对照组患者给予奥美拉唑治疗,病例组患者给予康复新液联合奥美拉唑治疗。观察比较两组患者的临床疗效;检测两组患者治疗前后的炎症因子水平;比较两组患者的不良反应发生情况;比较两组患者随访的胃溃疡复发情况。结果病例组患者的治疗总有效率为95.24%,高于对照组的78.57%,差异有统计学意义(P<0.05);两组患者治疗前的白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)水平比较,差异无统计学意义(P>0.05),治疗后的IL-6、TNF-α、CRP水平低于治疗前,差异有统计学意义(P<0.05);病例组患者治疗后的IL-6、TNF-α、CRP水平低于对照组,差异有统计学意义(P<0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05);随访2个月后复查胃镜,病例组患者的复发率(4.76%)低于对照组(19.05%),差异有统计学意义(P<0.05)。结论康复新液联合奥美拉唑治疗消化性溃疡的临床效果显著,具有协同作用,值得临床推广。

Objective To explore the clinical efficacy of Rehabilitation New Liquid combined with Omeprazole in the treatment of non-Helicobacter pylori infection peptic ulcer.Methods Altogether 84 patients with peptic ulcer who met the requirements in Affiliated Hospital of Jiujiang University from January 2017 to April 2018 were selected as subjects and randomly divided into case group and control group,with 42 cases in each group.The control group was treated with Omeprazole,while the case group was treated with Rehabilitation New Liquid combined with Omeprazole.The clinical effects of the two groups were observed and compared.The levels of inflammatory cytokines were measured before and after treatment in both groups.The adverse reactions of the two groups were compared.The recurrence of gastric ulcer was compared between the two groups during follow-up.Results The total effective rate of the patients in the case group was 95.24%,which was higher than that in the control group(78.57%),and the difference was statistically significant(P<0.05).The levels of interleukin-6(IL-6),tumor necrosis factorα(TNF-α)and C-reactive protein(CRP)in the two groups before treatment were not statistically significant(P >0.05),while the levels of IL-6,TNF-αand CRP after treatment were lower than before treatment,and the differences were statistically significant(P<0.05).The levels of IL-6,TNF-αand CRP in the case group after treatment were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the overall incidence of adverse reactions between the two groups(P >0.05).Gastroscopy review after 2 months of follow-up showed that the recurrence rate of patients in the case group(4.76%)was lower than that in the control group(19.05%),and the difference was statistically significant(P<0.05).Conclusion Rehabilitation New Liquid combined with Omeprazole is effective in the treatment of peptic ulcer,which has synergistic effect and is worthy of clinical promotion.