复方血栓通胶囊联合尼可地尔对ST段抬高型急性心肌梗死老年患者PCI术后无复流的干预效果

Effect of compound Xueshuantong capsule combined with nicorandil on no-reflow after PCI in elderly patients with ST-segment elevation acute myocardial infarction

目的分析复方血栓通胶囊联合尼可地尔对老年ST段抬高型急性心肌梗死患者PCI术后无复流的干预效果。方法选取本院2015年3月至2018年3月收治的PCI术后无复流老年ST段抬高型急性心肌梗死患者62例为研究对象,依据不同医治方案分为对照组和研究组,各31例。对照组行常规方案治疗,研究组在对照组的基础上行复方血栓通胶囊及尼可地尔联合治疗。比较两组患者的治疗效果。结果治疗前,两组患者心脏指数、左室舒张末期内径、左心射血分数比较,差异不显著(P>0.05);治疗后,两组患者心脏指数、左室舒张末期内径、左心射血分数均改善,且研究组优于对照组(P<0.05)。治疗前,两组患者肌钙蛋白I、脑钠肽、Ⅳ型胶原酶、超氧化物歧化酶水平比较,差异不显著(P>0.05);治疗后,两组患者肌钙蛋白I、脑钠肽、Ⅳ型胶原酶、超氧化物歧化酶水平均改善,且研究组优于对照组(P<0.05)。研究组心律失常总发生率低于对照组(P<0.05)。结论复方血栓通胶囊联合尼可地尔对老年ST段抬高型急性心肌梗死患者PCI术后无复流治疗效果显著,不仅可改善患者心功能及细胞因子水平,且有利于减少心律失常的发生,值得推广及应用。

Objective To analyze the effect of compound Xueshuantong capsule combined with nicorandil on no-reflow after PCI in elderly patients with ST-segment elevation acute myocardial infarction.Methods Sixty-two elderly patients with ST-segment elevation acute myocardial infarction who had no-reflow after PCI in our hospital from March 2015 to March 2018 were selected as the research objects.They were divided into control group and research group according to different treatment schemes,with 31 cases in each group.The control group received routine treatment,while the research group received combined treatment of compound Xueshuantong capsule and nicorandil on the basis of the control group.The therapeutic effects of the two groups were compared.Results Before treatment,there were no significant differences in cardiac index,left ventricular end-diastolic diameter and left ventricular ejection fraction between the two groups(P >0.05);after treatment,the cardiac index,left ventricular end-diastolic diameter and left ventricular ejection fraction of the two groups improved,and those in the research group were better than the control group(P<0.05).Before treatment,there were no significant differences in the levels of troponin I,brain natriuretic peptide,type Ⅳ collagenase and superoxide dismutase in the two groups(P >0.05);after treatment,the levels of troponin I,brain natriuretic peptide,type IV collagenase and superoxide dismutase in the two groups improved,and those in the research group were better than the control group(P<0.05).The total incidence of arrhythmia in the research group was lower than that in the control group(P<0.05).Conclusion Compound Xueshuantong capsule combined with nicorandil has a significant effect on no-reflow after PCI in elderly patients with ST-segment elevation acute myocardial infarction.It can not only improve cardiac function and levels of cytokines,but also reduce the incidence of arrhythmia.It is worth popularizing and applying.