依达拉奉注射液联合拉莫三嗪治疗脑卒中继发癫痫的效果及对血清NSE、SOD水平的影响

Effect of edaravone injection combined with lamotrigine on epilepsy secondary to stroke and its influence on serum NSE and SOD levels

目的探讨依达拉奉注射液联合拉莫三嗪治疗脑卒中继发癫痫的效果及对血清NSE、SOD水平的影响。方法将我院收治的脑卒中继发癫痫患者80例作为研究对象,按照随机数字表法将其分为对照组(n=40,拉莫三嗪治疗)和研究组(n=40,拉莫三嗪联合依达拉奉注射液治疗)。比较两组患者的临床治疗效果。结果研究组的治疗总有效率为95.00%,高于对照组的77. 50%(P<0.05);治疗后,两组患者癫痫发作频次、发作持续时间、NSE及SOD水平均改善,且研究组优于对照组(P<0.05);两组患者不良反应总发生率比较,差异不具有统计学意义(P>0.05)。结论依达拉奉注射液联合拉莫三嗪治疗脑卒中继发癫痫效果显著,不仅可改善癫痫发作情况,还能降低血清NSE、SOD水平,有助于改善预后效果。

Objective To study the effect of edaravone injection combined with lamotrigine on epilepsy secondary to stroke and its influence on levels of serum NSE and SOD.Methods A total of 80 patients with epilepsy secondary to stroke in our hospital were divided into control group(n=40,lamotrigine treatment)and study group(n=40,lamotrigine combined with edaravone injection treatment)according to random number table method.The clinical effects of treatment in the two groups were compated.Results The total effective rate of treatment in the study group was 95.00%,which was higher than 77.50%in the control group(P<0.05).After treatment,the seizure frequency,duration,levels of NSE and SOD in the two groups improved,and those in the study group were better than the control group(P<0.05).There was no significant difference in the total incidences of adverse reactions between the two groups(P >0.05).Conclusion Edaravone injection combined with lamotrigine in epilepsy secondary to stroke has a significant effect.It can not only improve the epilepsy situation,but also decreased the levels of serum NSE and SOD,which is helpful to improve the prognosis.