低分子肝素联合阿司匹林治疗高龄复发性流产的临床效果

Clinical effect of low molecular weight heparin combined with aspirin in the treatment of recurrent abortion in patients with advanced maternal age

目的探讨低分子肝素联合阿司匹林治疗高龄复发性流产的临床效果。方法将80例高龄复发性流产患者随机分为对照组和观察组,各40例。对照组应用阿司匹林治疗,观察组在对照组的基础上联合低分子肝素治疗。比较两组治疗效果。结果观察组的活产率和流产率显著优于对照组,妊娠并发症总发生率显著低于对照组(P<0.05)。两组不良反应总发生率无显著差异(P>0.05)。治疗后,两组APTT和D-二聚体水平均较治疗前显著改善(P<0.05),但组间比较无显著差异(P>0.05)。结论低分子肝素联合阿司匹林能够降低高龄复发性患者流产、妊娠并发症发生率,改善其凝血指标,安全性高,值得临床推广与应用。

Objective To investigate the clinical effect of low molecular weight heparin combined with aspirin in the treatment of recurrent abortion in patients with advanced maternal age.Methods Eighty cases of recurrent abortion patients with advanced maternal age were randomly divided into control group and observation group,with 40 cases in each group.The control group was treated with aspirin,while the observation group was treated with low molecular weight heparin on the basis of the control group.The therapeutic effects of the two groups were compared.Results The live birth rate and abortion rate in the observation group were significantly better than those in the control group,the total incidence of pregnancy complications was significantly lower than that in the control group(P<0.05).There was no significant difference in the total incidences of adverse reactions between the two groups(P >0.05).After treatment,the levels of APTT and Ddimer in the two groups significantly improved compared with those before treatment(P<0.05),but there were no significant differences between the two groups(P >0.05).Conclusion Low molecular weight heparin combined with aspirin can decrease the incidences of abortion and pregnancy complications in recurrent abortion patients with advanced maternal age,improve their coagulation indexes and have high safety.It is worthy of clinical promotion and application.