巴曲酶序贯蚓激酶治疗脑梗死的效果

Effect of sequential therapy of batroxobin and earthworm kinase on cerebral infarction

目的探讨巴曲酶序贯蚓激酶治疗脑梗死的临床效果。方法选取2012年1月至2018年1月我院收治的172例脑梗死患者为研究对象,根据用药方式将其分为对照组(86例,巴曲酶治疗)与观察组(86例,巴曲酶序贯蚓激酶治疗),比较两组患者的治疗效果。结果观察组患者的治疗总有效率显著高于对照组(P<0.05)。治疗前,两组患者的全血粘度高切、全血粘度低切、血浆粘度、红细胞聚集指数及纤维蛋白原水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的上述指标水平均明显降低,且观察组低于对照组,差异具有统计学意义(P<0.05);治疗前、后两组患者组间及组内的凝血酶原时间比较,差异无统计学意义(P>0.05)。治疗前,两组患者NIHSS及SF-36评分比较,差异无统计学意义(P>0.05);治疗后,两组患者NIHSS及SF-36评分均明显改善,且观察组优于对照组,差异具有统计学意义(P<0.05)。结论巴曲酶序贯蚓激酶治疗脑梗死效果显著,可以改善患者的血液高凝状态,提高患者的神经功能及生活质量水平,值得临床推广与应用。

Objective To investigate the clinical effect of sequential therapy of batroxobin and earthworm kinase on cerebral infarction.Methods A total of 172 patients with cerebral infarction admitted in our hospital from January 2012 to January 2018 were selected as the research objects.They were divided into control group(86 cases,batroxobin therapy)and observation group(86 cases,sequential therapy of batroxobin and earthworm kinase)according to the methods of medication.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that of the control group,the difference was statisticaly significant(P<0.05).Before treatment,there were no significant differences in the levels of whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,erythrocyte aggregation indexes and fibrinogen between the two groups(P >0.05).After treatment,the levels of above indexes in the two groups significantly decreased,and those in the observation group were lower than the control group,the differences were statistically significant(P<0.05).There were no significant differences in prothrombin time between and with in the two groups before and after treatment(P >0.05).Before treatment,there were no significant differences in the scores of NIHSS and SF-36 between the two groups(P >0.05);after treatment,the scores of NIHSS and SF-36 in the two groups significantly improved,and those in the observation group were better than the control group,the differences were statistically significant(P<0.05).Conclusion Sequential therapy of batroxobin and earthworm kinase is effective on cerebral infarction.It can improve the blood hypercoagulability,the neurological function and quality of life of patients.It is worthy of clinical promotion and application.