白癜风患者血清中IL-33和TNF-α水平的研究

Serum Levels of IL-33 and TNF-α in Patients with Vitiligo

目的:检测白癜风患者血清白介素-33(IL-33)和肿瘤坏死因子-α(TNF-α)水平,探讨IL-33和TNF-α水平与白癜风发生、发展之间的关系。方法:采用双抗体夹心酶联免疫吸附实验分别对41例白癜风患者及35例健康志愿者血清IL-33和TNF-α的水平进行检测,比较不同分期白癜风患者与正常对照组血清中IL-33和TNF-α水平。结果:白癜风组血清IL-33、TNF-α水平较健康对照组升高,差异具有统计学意义(P<0.05);进展期、稳定期白癜风患者血清IL-33、TNF-α水平高于健康对照组,且进展期高于稳定期,差异有统计学意义(P<0.05);白癜风患者血清IL-33和TNF-α水平之间存在正相关性(r=0.904,P<0.05)。结论:IL-33和TNF-α均作为促炎性因子参与了白癜风的发生、发展,血清水平可反映疾病进展情况。

Objective To evaluate the serum levels of IL-33 and TNF-α in patients with vitiligo,and to explore the relationship between IL-33 and TNF-α levels and the development of vitiligo. Methods The concentrations of IL-33 and TNF-α in serum were detected by enzyme linked immunosorbent assay (ELISA) in 41 patients with vitiligo and 35 healthy volunteers. The concentrations of IL-33 and TNF-α in the serum of patients with different stages of vitiligo and normal control were compared. Results The levels of IL-33 and TNF-α in the serum of patients with vitiligo were higher than those in the healthy control group. The difference was statistically significant (P <0.05).The levels of serum IL-33 and TNF-α in the advanced and stable phases were higher than those in the healthy control group, and the progression was higher than the stable phase. The difference was statistically significant.(P <0.05).There was a positive correlation between the expression level of IL-33 and TNF-α(r =0.904,P <0.05). Conclusion Vitiligo patients serum IL-33 and TNF-α are all proinflammatory factors involved in the pathogenesis of vitiligo, and serum levels can reflect disease progression.