腔隙性脑梗死患者睡眠与情感障碍及相关性研究

The correlation between sleep disorders and emotional disorders in patients with lacunar infarction

目的探讨腔隙性脑梗死患者睡眠与情感障碍及相关性。方法回顾性研究2014年9月至2017年6月就诊于神经内科的腔隙性脑梗死患者64例,对照组选取同期非脑血管病患者50例。腔隙性脑梗死患者与对照组患者均于就诊1 d～2周内进行匹兹堡睡眠质量指数量表(PSQI)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)测定,所有测试均一次完成。比较2组患者PSQI、HAMA、HAMD评分,并对腔隙性脑梗死患者PSQI评分与HAMA、HAMD评分进行相关性分析。结果腔隙性脑梗死患者PSQI总分及各因子评分除"睡眠效率"外均高于对照组(P <0. 05); HAMA总分及各因子评分明显高于对照组(P <0. 01); HAMD总分及相关因子中"焦虑/躯体化"、"睡眠障碍"、"迟缓"等因子评分均高于对照组(P <0. 05)。腔隙性脑梗死合并焦虑抑郁的患者睡眠质量较无焦虑抑郁患者差(P <0. 05),且腔隙性脑梗死患者眠障碍评分与情感障碍评分具有明显相关性(P <0. 01);焦虑与抑郁评分之间也存在着相关性(P <0. 05)。结论腔隙性脑梗死患者比一般患者更容易引起睡眠与情感障碍,且患者睡眠障碍与情感障碍具有明显相关性,应引起临床重视。

Objective To investigate the correlation between sleep disorders and emotional disorders in patients with lacunar infarction. MethodsThe data about 64 patients with lacunar infarction (observation group) and 50 patients with non-cerebrovascular disease (control group) who were admitted and treated in our hospital from September 2014 to June 2017 were retrospectively analyzed. The PSQI scores ,HAMA scores and HAMD scores were measured for all the patients during 1d^2 weeks after visiting doctor according to Pittsburgh sleep quality index scale (PSQI),Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD),and the score of PSQI,HAMA and HAMD were observed and compared between thw two groups. ResultsExcept for “sleep efficiency”,the PSQI scores and the factor scores in observation group were significantly higher than those in control group ( P <0.05),and HAMA score and each factor score were significantly higher than those in control group ( P <0.01). The total scores of HAMD and the scores of “anxiety/somatization”,“sleep disorder” and “slowing” in related factors in observation group were significantly higher than those in control group ( P <0.05).Moreover the sleep quality in patients with lacunar infarction complicated by anxiety-depression was inferior to that in patients without anxiety-depression ( P <0.05).Moreover the scores of sleep disorder were closely related to emotional disorder scores in patients with lacunar infarction,and anxiety scores were related with those of depression ( P <0.05). ConclusionAs compared with general patients,the patients with lacunar infarction are more likely to suffer from sleep disorder and emotional disorder,moreover, there is close correlation between sleep disorder and emotional disorder in patients with lacunar infarction,therefore,it is should be paid much attention to in clinical practice.