血浆脂蛋白相关磷脂酶A2、超敏C反应蛋白联合载脂蛋白E检测在脑梗死诊断中的应用价值

The application value of combined detection of LP-PLA2,hs-CRP and ApoE in the diagnostic process of cerebral infarction

探讨血浆脂蛋白相关磷脂酶A2(LP-PLA2)、超敏C反应蛋白(hs-CRP)联合载脂蛋白E(ApoE)检测在脑梗死中的诊断价值。以本院收治的120例脑梗死患者(脑梗死组)作为研究对象,同时以此期间的健康体检正常人群(n=120)作为对照人群(正常组)。比较上述两组血清LP-PLA2、hs-CRP、ApoE的水平,并对单独或联合检测脑梗死患者上述指标进行统计学分析。脑梗死组患者LP-PLA2、hs-CRP、ApoE水平明显高于正常组(P<0.05),联合检测LP-PLA2、hs-CRP、ApoE的敏感度、特异度、准确度最高(P<0.05),且此时ROC曲线面积最大。联合检测LP-PLA2、hs-CRP、ApoE能明显提高脑梗死的准确度与敏感度,并增强其诊断特异性,具有重要的临床应用价值。

To investigate the diagnostic value of plasma lipoprotein related phospholipase A2 (LP-PLA2), hypersensitive C reactive protein (hs-CRP) combined with apolipoprotein E (ApoE) in the diagnosis of cerebral infarction. In our hospital, 120 patients with cerebral infarction (cerebral infarction group) were treated as the subjects. At the same time, the normal healthy population (n =120) was used as the control group (normal group). The serum LP-PLA2, hs- CRP and ApoE levels of the two groups were compared, and the above indexes of patients with cerebral infarction were statistically analyzed separately or jointly. The levels of LP-PLA2, hs-CRP and ApoE in the patients with cerebral infarction were significantly higher than those of the normal group (P<0. 05). The sensitivity, specificity and accuracy of LP-PLA2, hs-CRP and ApoE were the highest (P<0. 05), and the area of ROC curve was the largest at this time. Combined detection of LP-PLA2, hs-CRP and ApoE can obviously improve the accuracy and sensitivity of cerebral infarction, and enhance the specificity of its diagnosis. It has important clinical value.