CA125联合子宫内膜息肉检测诊断早期子宫内膜异位症的价值

Value of CA125 combined with endometrial polyp in diagnosis of early endometriosis

目的 探讨CA125联合子宫内膜息肉检测诊断早期子宫内膜异位症的价值。方法 对2010年1月至2015年12月于佛山市第一人民医院诊治的1 049例不明原因性不孕患者的资料进行回顾性分析。结果 血清CA125升高预测早期内膜异位症的灵敏度为77.69%,特异度为31.45%。子宫内膜息肉预测早期内膜异位症的灵敏度为84.21%,特异度为33.84%。CA125联合内膜息肉预测早期内异症的灵敏度为93.27%,特异度为31.75%。血清CA125(阳性)与CA125(阳性)联合内膜息肉作对比,两者均为诊断早期内异症的预测指标,其方法差异有统计学意义,P=0.0004。结论 血清CA125联合子宫内膜息肉作为诊断早期子宫内膜异位症的预测指标,灵敏度高,特异性低。若不孕症患者2项指标同时阳性,应高度怀疑其有早期子宫内膜异位症的可能,可适当放宽腹腔镜探查指征。

Objective To explore the value of CA125 combined with endometrial polyp in the diagnosis of early endometriosis.Methods The data of 1 049 cases of reason-unknown infertility diagnosed and treated at Foshan First People's Hospital from Jan.2010 to Dec.2015.were retrospectively analyzed.Results The raise of serum CA125 had a sensitivity of 77.69%to the prediction of early endometriosis,and a specificity of 31.45%.Endometrial polyp had a sensitivity of 84.21%to the prediction of early endometriosis,and a specificity of 33.84%.CA125 and endometrial polyp together had a joint sensitivity of 93.27%to the prediction of early endometriosis,and a specificity of 31.75%.By comparing serum CA125(positive)to CA125(positive)and endometrial polyp,we realized that both of them were predictive indexes for diagnosing early endometriosis,with a statistical difference(P=0.004).Conclusion Serum CA125 combined with endometrial polyp are predictive indexes,with a high sensitivity and a low specificity,for diagnosing early endometriosis.If an infertile patient is positive in both indexes,the probability of early endometriosis should be seriously taken into account,and the indication of laparoscopic exploration can be relaxed appropriately.