高血压合并T2DM患者血清Hcy、UA、ICAM-1、MMP-9与IMT的关系

Correlation of IMT with serum levels of Hcy,UA,ICAM-1,and MMP-9 in hypertensive patients complicated with T2DM

目的 探讨高血压伴2型糖尿病(T2DM)患者血清同型半胱氨酸(Hcy)、尿酸(UA)、细胞间粘附分子-1(ICAM-1)、基质金属蛋白酶9(MMP9)与颈动脉内膜中层厚度(IMT)的关系。方法 随机选取本院2018年1月至8月确诊的高血压伴T2DM患者90例(合并组)、单纯高血压患者90例(高血压组)、健康体检对象90例(对照组),检测3组血清Hcy、UA、ICAM-1、MMP-9、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及颈动脉IMT,并分析其相互关系。结果 对照组、高血压组血清TG、TC、HDL-C、LDL-C水平差异无统计学意义(均P >0.05);合并组血清TG、TC、LDL-C水平高于高血压组和对照组(均P<0.05),血清HDL-C水平低于高血压组和对照组(均P<0.05);合并组和高血压组血清Hcy、UA、ICAM-1、MMP-9水平显著高于对照组(均P<0.05);合并组血清Hcy、UA、ICAM-1、MMP-9水平显著高于高血压组(均P<0.05);合并组和高血压组IMT测定值显著高于对照组(均P<0.05);合并组IMT测定值显著高于高血压组(P<0.05);高血压合并T2DM患者血清Hcy、UA、ICAM-1、MMP-9水平与IMT均呈显著正相关关系(均P<0.05)。结论 高血压合并T2DM患者血清Hcy、UA、ICAM-1、MMP-9水平升较单纯高血压或健康人群高,并且与患者颈动脉粥样硬化有关。

Objective To investigate the correlation of carotid intima-media thickness(IMT)with serum levels of homocysteine(Hcy),uric acid(UA),intercellular adhesion molecule-1(ICAM-1),and matrix metalloproteinase-9(MMP9)in hypertensive patients complicated with type 2 diabetes mellitus(T2DM).Methods 90 hypertensive patients with type 2 diabetes mellitus(a combined group),90 hypertensive patients(a hypertension group),and 90 healthy objects(a control group)diagnosed or examined at our hospital from January to August,2018 were randomly selected.The serum levels of Hcy,UA,ICAM-1,MMP-9,triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)as well as carotid IMT were measured in the three groups,and their correlations were analyzed.Results There were no statistical differences in the serum levels of TG,TC,HDL-C,and LDL-C between the control group and the hypertension group(all P >0.05).The serum levels of TG,TC,and LDL-C were higher and the serum HDL-C level was lower in the combined group than in the hypertension group and the control group(all P<0.05).The serum levels of Hcy,UA,ICAM-1,and MMP-9 in the combined group and hypertension group were significantly higher than those in the control group(all P<0.05).The serum levels of Hcy,UA,ICAM-1,and MMP-9 in the combined group were significantly higher than those in the hypertensive group(all P<0.05).The IMT values in the combined group and the hypertension group were significantly higher than that in the control group(both P<0.05);the IMT value in the combined group was significantly higher than that in the hypertension group(P<0.05).The serum levels of Hcy,UA,ICAM-1,and MMP-9 in the hypertensive patients with T2DM positively correlated with IMT(all P<0.05).Conclusion The serum levels of Hcy,UA,ICAM-1,and MMP-9 in hypertensive patients complicated with T2DM are higher than those in patients with hypertension or healthy people,and relate to carotid atherosclerosis.