影响COPD患者急性加重期发生多器官功能衰竭的因素研究

Study on the factors affecting multiple organ failure in patients with acute exacerbation of COPD

目的 分析影响COPD患者急性加重期发生多器官功能衰竭的因素。方法 选取本院在2017年3月至2018年3月间收治的COPD患者56例,对其进行资料分析,观察急性加重期多器官功能衰竭的相关因素。结果 应用Logistic回归分析进行MODS危险因素单因素分析,患者的治疗时间、发病到痊愈的病程、肺炎与持续发热等症状、有创通气等条件均为危险因素。但患者病程的回归系数已经达到了1.192,而患者接受治疗期间的有创通气回归系数则已经达到了6.26,通常对其OR与95%可信区间比较差异有统计学意义(P<0.05);在功能器官衰竭2个、衰竭3个方面,年龄在60岁及以上的患者显著高于年龄在60岁以下的患者,差异有统计学意义(P<0.05);在功能器官衰竭4个方面,不同年龄段患者比较差异无统计学意义(P<0.05)。结论 通过本次研究可以发现,年龄在60岁以上的患者,2个以上器官发生功能衰竭时其预后并不良好,因此必须要予以该方面的关注。临床必须要根据具体影响因素制定预防和治疗方案,以此保障患者的健康。

Objective To analyze the factors that affect the multiple organ failure in patients with acute exacerbation of COPD.Methods 56 cases of COPD were selected from March 2017 to March 2018 in our hospital,the clinical data were analyzed,and the related factors of multiple organ failure in acute exacerbation were observed.Results According to statistics and analysis,the risk factors included the course of disease,treatment time,invasive ventilation,pneumonia and persistent fever;multi factor non conditional logistic regression analysis results showed that,the regression coefficient of the course of disease was 1.192,and the regression coefficient of invasive ventilation was 6.26,usually there were statistically significant differences in the odds ratio(OR)and 95%confidence interval(P<0.05).In patients with 2,3 organs failures,the ratio of over 60 years old was significantly higher than the ratio of under 60 years old;there was no significant difference in patients with 4 organs failures.Conclusion In patients equal to or greater than 60 years old,with the combination of 2 and above organs failures,the prognosis is worse.