大连沙河口区妊娠期妇女血脂、总蛋白和白蛋白参考范围的建立

Establishment of normal reference levels of blood lipid,total protein,and albumin in pregnancy in Shahekou

目的 探讨正常孕妇血脂、总蛋白和白蛋白变化趋势,初步建立妊娠期血脂、总蛋白和白蛋白参考范围。方法 选择2016年1月至2017年11月在本院产检的1 500例孕妇作为研究对象,按孕周分为孕早期组(<14周以前)、孕中期组(14~27周)、孕晚期组(28~40周),各500例。选择同期500例非孕健康体检妇女作为对照组,建立孕妇血脂、总蛋白和白蛋白参考值范围。结果 孕妇总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平在孕晚期(6.09±1.06)mmol/L、(3.26±0.89)mmol/L、(3.68±0.90)mmol/L,明显高于孕早期、孕中期和非妊娠妇女,总蛋白(TP)、白蛋白(ALB)水平在孕晚期(62.19±4.30)g/L、(31.74±4.86)g/L,明显低于孕早、孕中期和非妊娠妇女,差异均有统计学意义(均P<0.05);高密度脂蛋白胆固醇(HDL-C)早孕、中孕和晚孕水平与非妊娠妇女比较,差异无统计学意义(P >0.05);孕晚期TC参考值:5.01~8.17 mmol/L,TG:1.52~5.00 mmol/L,LDL-C:1.92~5.44 mmol/L,HDL-C:1.03~2.33 mmol/L,TP:53.76~70.62 g/L,ALB:22.21~41.27 g/L。结论 孕妇血脂及蛋白水平在孕期随妊娠时间逐渐改变,尤其晚孕期达到峰值。建立正常孕妇早、中、晚孕期的血脂及蛋白参考值范围具有重要的临床意义。

Objective To investigate the blood lipid,total protein(TP),and albumin(ALB)trends in normal pregnant women,build gestational blood lipid,TP,and ALB reference range.Methods 1 500 pregnant women were chosen as the research objects from 2016.1 to 2017.11 in our hospital,including 500 cases of first trimester(<14 weeks),500 cases of midtrimester(14-27 weeks),and 500 cases of last trimester(28-40 weeks),and 500 cases of non-pregnant health check-up during the same period as the control to establish the reference range of blood lipid,TP,and ALB.Results The levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),TP,ABL in last trimester group were(6.09±1.06)mmol/L,(3.26±0.89)mmol/L,(3.68±0.90)mmol/L,significantly higher than those in the first trimester group,midtrimester group,control group,the levels of total protein(TP),albumin(ALB)in last trimester group were(62.19±4.30)g/L,(31.74±4.86)g/L,significantly lower than those in the first trimester group,midtrimester group,control group,with statistically significant differences(P<0.05);there was no statistically significant difference in the level of HDL-C among the four groups(P >0.05).The reference range of TC in the last trimester was 5.01-8.17 mmol/L,TG:1.52-5.00 mmol/L,LDL-C:1.92-5.44 mmol/L,HDL-C:1.03-2.33 mmol/L,TP:53.76-70.62 g/L,ALB:22.21-41.27 g/L.Conclusions Blood lipid and protein levels in pregnant women change with pregnancy time,the peak occurs at the last trimester.It has important clinical significance to establish the reference range of normal blood lipid and protein in pregnant women.