双歧杆菌四联活菌在腹泻型肠易激综合征治疗中的应用效果及对血清5-羟色胺、P物质的影响

Effect of viable bifidobacterium quadruple tablets in the treatment of diarrhea induced irritable bowel syndrome and its effect on serum 5-serotonin and substance P

目的 分析双歧杆菌四联活菌在腹泻型肠易激综合征治疗中的应用效果及对血清5-羟色胺、P物质的影响。方法 将90例腹泻型肠易激综合征患者随机分为两组:常规组45例予以马来酸曲美布汀联合地衣芽孢杆菌治疗,研究组45例在常规组治疗的基础上予以双歧杆菌四联活菌治疗,两组患者均治疗8周。比较两组患者临床疗效、消化道症状及血清5-羟色胺、P物质水平。结果 治疗8周后,研究组总有效率为93.33%,高于常规组的77.78%,差异有统计学意义(P<0.05);研究组症状频率评分及症状程度评分均低于常规组,差异有统计学意义(P<0.05);研究组大便性状及大便次数恢复正常时间均短于常规组,差异有统计学意义(P<0.05);研究组血清5-羟色胺、P物质水平均低于常规组,差异有统计学意义(P<0.05)。结论 在常规胃肠动力药治疗的基础上加用双歧杆菌四联活菌辅助治疗,能够提高腹泻型肠易激综合征的治疗效果,其可能与减少5-羟色胺、P物质释放相关。

Objective To analyze the effect of viable bifidobacterium quadruple tablets in the treatment of diarrhea induced irritable bowel syndrome and its effect on serum 5-serotonin and substance P.Methods 90 cases of diarrhea type irritable bowel syndrome were randomly divided into two groups.45 cases in the conventional group were treated with trimebutine maleate combined with Bacillus licheniformis,on the basis of the conventional group therapy,45 cases in the study group were treated with viable bifidobacterium quadruple tablets.The two groups were treated for 8 weeks.The clinical efficacy,digestive tract symptoms,serum 5-serotonin and substance P levels were compared between the two groups.Results After 8 weeks of treatment,the total effective rate of the study group was 93.33%,which was higher than that of the conventional group(77.78%),with statistically significant difference(P<0.05);the scores of symptom frequency and symptom degree of the study group were lower than those of the conventional group,with statistically significant differences(P<0.05);the recovery time of the characters and times of stool of the study group were shorter than those of the conventional group,with statistically significant differences(P<0.05);the levels of serum 5-serotonin and substance P of the study group were lower than those of the conventional group,with statistically significant differences(P<0.05).Conclusion On the basis of routine gastrointestinal motility drug therapy plus viable bifidobacterium quadruple adjuvant therapy can improve the therapeutic effect of diarrhea induced irritable bowel syndrome,which may be related to the reduction of 5-serotonin and substance P release.