两种苦参碱缓释微粒的释放动力学研究

Study on the Release Kinetics of Two Kinds of Matrine Sustained-release Microcapsules

对比苦参碱的市售粉剂、脂质体及蛋白微囊在实验室静态水与模拟大田实验流动态的水中的释放差异,探究释放规律。设计实验室模拟静态释放和动态释放,并通过Origin 8.0进行模型拟合。结果市售粉剂、脂质体及蛋白微囊在静态和动态释放过程中均符合一级动力学模型(r>0.99),其中市售苦参碱粉剂在Ritger-peppas模型中的药物释放因子n<0.45,脂质体及微囊在Ritger-peppas模型中的药物释放因子0.45<n<0.89。在4h内,市售苦参碱粉剂释放规律以扩散为主,脂质体及微囊释放规律以扩散和溶蚀协同作用。

Commercially available powders,liposomes and protein microcapsules of Matrine were compared the difference of release in standing water and flowing water to research the release characteristics.Origin 8.0 was been used to analyzed and fitted the equation.The commercially available powders,liposomes and protein microcapsules were consistent with the first-order kinetic model(r >0.99)both in standing water and flowing water.The pharmacokinetic factor of commercially available Matrine powder in the Ritger-peppas model was less than 0.45,the pharmacokinetic factor of liposomes and protein microcapsules in the Ritger-peppas model was between 0.45 and 0.89.The release of commercially available matrine powder is focused on diffusion within 4 h,while the release of liposomes and protein microcapsules are focused on the couple of diffusion and erosion model.