血清新型细胞角蛋白联合肿瘤标志物检测在非小细胞肺癌诊断中的应用

Implication of Combined Detection of Novel Cytokeratin Biomarker Monototal and Tumor Markers in Diagnosis of Non-small Cell Lung Cancer

目的:探讨血清新型细胞角蛋白标志物Monototal联合其他肿瘤标志物在非小细胞肺癌诊断的临床价值。方法:检测非小细胞肺癌患者126例(肺鳞癌67例、肺腺癌59例,非小细胞肺癌组)、肺部良性疾病患者68例(肺部良性疾病组)和健康人群45例(健康对照组)血清中细胞角蛋白19片段(CYFRA21-1)、糖类抗原153(CA153)、神经元特异烯醇化酶(NSE)及新型细胞角蛋白标志物Monototal水平,并统计分析其敏感性和特异性。结果:非小细胞肺癌组血清CYFRA21-1、CA153、NSE及Monototal水平均显著高于肺部良性疾病组及健康对照组,比较差异均有统计学意义(P<0.05);非小细胞肺癌组血清CYFRA21-1、CA153、NSE及Monototal阳性率显著高于肺部良性疾病组及健康对照组,比较差异均有统计学意义(P<0.05),敏感性分别为66.7%、32.5%、40.4%及77.8%;各项肿瘤标志物单检对非小细胞肺癌诊断的灵敏度分别为66.7%、32.5%、40.4%和77.8%,4项指标联合检测的敏感性为89.7%,显著高于单项检测指标,比较差异均有统计学意义(P<0.05)。结论:Monototal联合CYFRA21-1、CA153、NSE检测能提高非小细胞肺癌诊断的灵敏性。

Objective:To observe the clinical value of combined detection of novel cytokeratin biomarker Monototal and tumor markers in diagnosis of non-small cell lung cancer.Method:Levels of serum CYFRA21-1,CA153,NSE and Monototal in 126 non-small cell lung cancer patients(67 squamous carcinoma cases,59 adenocarcinoma cases,non-small cell lung cancer group),68 benign pulmonary diseases patients(benign pulonary diseases group)and 45 healthy volunteers(healthy control group)were measured and their sensitivity and specificity were analyzed.Result:The levels of serum CYFRA21-1,CA153,NSE and Monototal in nonsmall cell lung cancer group were greatly increased compared with the benign pulmonary diseases group and healthy control group (P<0.05).The non-small cell lung cancer group had significantly higher positive rate in serum CYFRA21-1,CA153,NSE and Monototal than the benign pulmonary diseases group and health control group (P<0.05),with sensitivity respectively as 66.7%,32.5%,40.4% and 77.8%.Single indicator detection had sensitivity of nonsmall cell lung cancer respectively as 66.7%,32.5%,40.4% and 77.8%,which was 89.7% in combined detection of 4 indicators.The combined detection had higher sensitivity than single indicator detection,the difference had statistical significance(P<0.05).Conclusion:Combined detection of serum CYFRA21-1,CA153,NSE and Monototal can improve the sensitivity of non-small cell lung cancer diagnosis.