摘要
急性早幼粒细胞白血病(APL)是一种以骨髓异常早幼粒细胞增多、造血功能衰竭并伴t(15;17)(q22;q21)染色体异位为特征的特殊类型白血病。经历了蒽环类化疗药物、全反式维甲酸(ATRA)、亚砷酸(ATO)的时代变迁,APL最终成为一种可治愈的血液系统恶性肿瘤,但儿童APL的总体疗效较成人差。本文将对儿童APL治疗进展做一简要概括。
Acute promyelocytic leukemia(APL)is a special type of leukemia characterized by abnormal promyelocytic cells in bone marrow,life-threatening hematopoietic failure and the chromosome translocation t(15;17)(q22;q21).After the changes of anthracycline chemotherapeutic drugs,all-trans retinoic acid(ATRA)and arsenic trioxide(ATO),APL eventually becomes a curable malignant hematological malignancy,but the overall efficacy of APL in children is worse than that in adults.This article will briefly summarize the progress in treatment of childhood APL.
作者
金婷婷
裴仁治
JIN Tingting;PEI Renzhi(Medical College of Ningbo University,Ningbo 315211,China)
出处
《中国医学创新》
CAS
2019年第4期165-168,共4页
Medical Innovation of China
